BDB -BiopanningDataSet Details

Biopanning Data

BiopanningDataSet ID: 2274

Peptides:

Sequences
EGHEHQTSWWEL(1) QDKLTQWPKWLE(5) HTSVERWPLWLE(1) ITPWPHWLERSS(1) TTTTSVWPAWLE(2)

Sequences Features:

Motif:

W-P-x-W-L-E

Unique Sequence Number:

Experimental Method:

Phage display (subtractive panning)

Sequencing Platform:

Sequencing Method:

Sanger sequencing

Rounds of Panning:

Reference:

PMID: 16223774

Target Name:

Anti-CD20 monoclonal antibody rituximab

Template Name:

B-lymphocyte antigen CD20

Structure of Target-Template Complex:

Not determined.

Structure of Target-Peptide Complex:

Not determined.

Library Name:

Ph.D.-12 phage display library (X12)

Affinity Measurement Method:

Affinity Measurement Description:

Brief Description:

At each round, phage particles binding to isotypic and allotypic determinants of rituximab were removed by a preadsorption step on the rituximab isotype-matched infliximab.

BiopanningDataSet Comments:

The epitope(s) recognized by Rp5-L (QDKLTQWPKWLE) is within the rituximab Ag-combining site.

Curator:

Curation Date:

0000-00-00

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