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General information
AgoID:	Ago0002
Accession:	Q9UKV8.3
ProteinName:	Protein argonaute-2
AlternativeNames:	(Argonaute2) (hAgo2) (EC 3.1.26.n2) (Argonaute RISC catalytic component 2) (Eukaryotic translation initiation factor 2C 2) (eIF-2C 2) (eIF2C 2) (PAZ Piwi domain protein) (PPD) (Protein slicer)
Organism:	Homo sapiens (Human)
AgoType:	eAgo
Experimentally-verified:	Yes
ProteinSequence:	Q9UKV8.3.fasta
SequenceLength:	859
GeneName:	AGO2,EIF2C2
GeneID:	27161
LocusTag:
CodingRegion:	NC_000008.11 (140520156..140642406, complement)
GO enrichment:	GO terms: positive regulation of trophoblast cell migration GO:1901165
	negative regulation of amyloid precursor protein biosynthetic process GO:0042985
	production of siRNA involved in RNA interference GO:0030422
	siRNA binding GO:0035197
	positive regulation of nuclear-transcribed mRNA poly(A) tail shortening GO:0060213
	mRNA cap binding complex GO:0005845
	RNA 7-methylguanosine cap binding GO:0000340
	negative regulation of translational initiation GO:0045947
	positive regulation of nuclear-transcribed mRNA catabolic process deadenylation-dependent decay GO:1900153
	gene silencing by RNA GO:0031047
	translation initiation factor activity GO:0003743
	post-embryonic development GO:0009791
	translational initiation GO:0006413
	positive regulation of angiogenesis GO:0045766
	translation GO:0006412
	protein C-terminus binding GO:0008022
	cell junction GO:0030054
	dendrite GO:0030425
	core promoter sequence-specific DNA binding GO:0001046
	RNA polymerase II complex binding GO:0000993
	polysome GO:0005844
	regulation of gene silencing by miRNA GO:0060964
	ribonucleoprotein complex GO:1990904
	positive regulation of transcription by RNA polymerase II GO:0045944
	endoribonuclease activity GO:0004521
	RNA phosphodiester bond hydrolysis endonucleolytic GO:0090502
	RNA binding GO:0003723
	nucleoplasm GO:0005654
	miRNA metabolic process GO:0010586
	nucleus GO:0005634
	mRNA cleavage involved in gene silencing by miRNA GO:0035279
	miRNA loading onto RISC involved in gene silencing by miRNA GO:0035280
	RNA secondary structure unwinding GO:0010501
	RISC-loading complex GO:0070578
	post-transcriptional gene silencing by RNA GO:0035194
	miRNA mediated inhibition of translation GO:0035278
	production of miRNAs involved in gene silencing by miRNA GO:0035196
	RISC complex GO:0016442
	pre-miRNA processing GO:0031054
	miRNA binding GO:0035198
	Wnt signaling pathway calcium modulating pathway GO:0007223
	single-stranded RNA binding GO:0003727
	double-stranded RNA binding GO:0003725
	P-body GO:0000932
	negative regulation of gene expression GO:0010629
	positive regulation of gene expression GO:0010628
	cytoplasm GO:0005737
	cytosol GO:0005829
	protein binding GO:0005515
	metal ion binding GO:0046872
	membrane GO:0016020

Domain information
DomainAnnotation:
DomainSequence:
DmReference:	PMID:22539551
DomainSource:	literature