Welcome to CASPredict home page! CASPredict is an online service tool that can quickly identify CRISPR-associated (Cas) proteins from protein sequences submitted by users.
Clustered regularly interspaced short palindromic repeats (CRISPR) and their associated (Cas) proteins constitute the CRISPR-Cas systems, which play a key role in prokaryote adaptive immune system against invasive foreign elements. In recent years, the CRISPR-Cas systems have also been designed to facilitate target gene editing in eukaryotic genomes. As one of the important components of the CRISPR-Cas system, Cas protein plays an irreplaceable role. The effector module composed of Cas proteins is used to distinguish the type of CRISPR-Cas systems. Effective prediction and identification of Cas proteins can help biologists further infer the type of CRISPR-Cas systems. At the same time, the class 2 CRISPR-Cas systems are gradually applied in the field of genome editing, so the discovery of Cas protein will help provide more candidates for genome editing. According to our latest statistics, there are only 293 Cas proteins that have been manually reviewed in the Uniprot. Many potential Cas proteins have yet to be discovered and these potential Cas proteins can not only provide candidates for gene editing tools, but also help us understand prokaryote adaptive immune system deeply. Therefore, it is urgent to develop an efficient and cheap tool to rapidly identify new Cas proteins from massive biological data and provide more reliable data resources for the reserch of CRISPR-Cas systems.
The CASPredict is a novel web service of Cas proteins based on support vector machine (SVM), which can help users find more new Cas proteins and accelerate the functional research of Cas proteins.
