DOTAD

Network

Statistics

Source-aware statistical views of DOTAD 2.0. The resource landscape uses all curated records with source tracking, while comparative developability analyses are restricted to a harmonized antibody-level subset with comparable internal assays.

Interactive explorer

Dynamic statistics for database browsing

These web-native charts keep the source-aware rules from the DOTAD 2.0 analysis pipeline, while adding tooltip, hover, and load-time animation for faster browsing.

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Key assay-family coverage

Antibody-level presence across all curated linked measurement records.

Animated bars

Format-associated completeness

Coverage heatmap across metadata-defined format groups with usable format-level sample size.

Hover cells

Interactive PCA of the harmonized assay space

Complete-case antibodies from the harmonized internal subset. Hover points to inspect antibody identity and annotation.

Publication figures

Static figure exports aligned with the manuscript

The publication-style SVG, PNG, and PDF figure bundles remain available below for direct figure reuse and citation-aligned viewing.

Resource landscape

Composition and coverage across DOTAD 2.0

Integrated view of metadata composition, assay-family coverage, format-associated completeness, and antibody-level missingness.

DOTAD 2.0 composition and coverage landscape

All curated records retained for coverage summaries Source identity preserved

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Harmonized subset

Statistical structure of therapeutic developability phenotypes

Distribution, correlation, format-associated comparison, and PCA were computed only on the source-aware harmonized internal assay subset.

DOTAD 2.0 developability statistical structure

Numeric pooling restricted to comparable internal assays Literature values not force-merged into PCA or correlations

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Supplementary views

Supporting source and sensitivity checks

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Source-by-assay coverage

Literature/source contribution patterns across assay categories.

Rank-based correlation check

Sensitivity view for non-Gaussian assay distributions.

Internal cohort check

PCA recolored to inspect cohort-specific structure.