Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 987 |
| PDBID: | 4UBD |
| Chains: | GH_F |
| Organism: | Influenza A virus (A/Hong Kong/1/1968(H3N2)), Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 3.50 |
| Reference: | 10.1038/ncomms8708 |
| Antibody | |
| Antibody: | CT149 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | Navivumab(Preclinical) |
| Antigen | |
| Antigen: | Influenza A virus H3N2 hemagglutinin |
| Antigen mutation: | No |
| Durg Target: | P03437 |
Sequence information
Antibody
Heavy Chain: G
Mutation: NULL
| >4UBD_G|Chain M[auth C], O[auth G], Q[auth K], S[auth O], U[auth S], W[auth Y]|monoclonal antibody H chain|Homo sapiens (9606) QVQLVQSGAEVKKPGASVKVSCKTSGYSFSTYGVSWVRQAPGQGPEWVGWISAYTGITDYAQKFQGRVTLTTDATTATAFLDLRSLRPDDTATYFCARDKVQGRVEVGSGGRHDYWGQGTLVIVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEP |
Light Chain: H
Mutation: NULL
| >4UBD_H|Chain N[auth D], P[auth H], R[auth L], T[auth P], V[auth T], X|monoclonal antibody L chain|Homo sapiens (9606) EVVLTQSPGTLALPPGERATLSCRASHRVGSTYIAWYQQKSGQAPRRLIYGASNRATDIPDRFSGSGSGTDFTLTIRRLEPEDSAVYYCQQFSVSPWTFGQGTRVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: F
Mutation: NULL
| >4UBD_F|Chain C[auth B], H[auth F], I[auth J], J[auth N], K[auth R], L[auth V]|Hemagglutinin HA2 chain|Influenza A virus (506350) GLFGAIAGFIENGWEGMIDGWYGFRHQNSEGTGQAADLKSTQAAIDQINGKLNRVIEKTNEKFHQIEKEFSEVEGRIQDLEKYVEDTKIDLWSYNAELLVALENQHTIDLTDSEMNKLFEKTRRQLRENAEDMGNGCFKIYHKCDNACIESIRNGTYDHDVYRDEALNNRFQIKG |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| G: TYR54 THR55 ILE57 LYS100 VAL101 GLN102 GLY103 ARG104 VAL105 GLU106 VAL107 GLY108 SER109 H: GLY30 SER31 THR32 TYR33 GLY51 SER53 ASN54 SER68 F: ASP19 GLY20 TRP21 LEU38 LYS39 THR41 GLN42 ILE45 ASP46 ILE48 ASN49 GLY50 LEU52 ASN53 ILE56 GLU57 LYS58 ASN60 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
