Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 977 |
| PDBID: | 4U1G |
| Chains: | BC_A |
| Organism: | Plasmodium falciparum, Mus musculus |
| Method: | XRD |
| Resolution (Å): | 3.10 |
| Reference: | 10.1038/nature13715 |
| Antibody | |
| Antibody: | QA1 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Plasmodium falciparum reticulocyte-binding protein homologue 5 (PfRH5) |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: B
Mutation: NULL
| >4U1G_B|Chain B, E|QA1 monoclonal antibody heavy chain|Mus musculus (10090) MGWSWIFLFLLSGTAGVHSEVQLVESGGGLVKPGGSLKLSCAASGFTFSDFYMYWVRQTPEKRLEWVATISDGDSYIYYPDSVRGRFTISRDNAKNILFLQMSSLKSEDTAMYFCARDGNGKDGGDAMDYWGQGTSVTVSSAKTTAPSVYPLAPVCGDTTGSSVTLGCLVKGYFPEPVTLTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVTSSTWPSQSITCNVAHPASSTKVDKKIEPRGPTIKPCPPCKCPAPNS |
Light Chain: C
Mutation: NULL
| >4U1G_C|Chain C, F|QA1 monoclonal antibody light chain|Mus musculus (10090) MVSTPQFLVFLLFWIPASRGDIVLTQSPASLAVSLGQRATISCRASQSVSTSSYTYFHWYQQKPGQPPKLLIRYASNLESGVPARFSGSGSGTDFTLNIHPVEEEDTATYYCQHSWEIPYTFGGGTKLEIKRADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNRNEC |
Antigen
Chain: A
Mutation: NULL
| >4U1G_A|Chain A, D|Reticulocyte binding protein 5|Plasmodium falciparum (5833) MIRIKKKLILTIIYIHLFILNRLSFENAIKKTKNQENNLTLLPIKSTEEEKDDIKNGKDIKKEIDNDKENIKTNNAKDHSTYIKSYLNTNVNDGLKYLFIPSHNSFIKKYSVFNQINDGMLLNEKNDVKNNEDYKNVDYKNVNFLQYHFKELSNYNIANSIDILQEKEGHLDFVIIPHYTFLDYYKHLSYNSIYHKSSTYGKYIAVDAFIKKINEAYDKVKSKCNDIKNDLIATIKKLEHPYDINNKNDDSYRYDISEEIDDKSEETDDETEEVEDSIQDTDSNHTPSNKKKNDLMNRTFKKMMDEYNTKKKKLIKCIKNHENDFNKICMDMKNYGTNLFEQLSCYNNNFCNTNGIRYHYDEYIHKLILSVKSKNLNKDLSDMTNILQQSELLLTNLNKKMGSYIYIDTIKFIHKEMKHIFNRIEYHTKIINDKTKIIQDKIKLNIWRTFQKDELLKRILDMSNEYSLFITSDHLRQMLYNTFYSKEKHLNNIFHHLIYVLQMKFNDVPIKMEYFQTYKKNKPLTQ |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| B: SER30 ASP31 TYR33 TYR35 THR50 ASP53 GLY54 SER56 TYR57 TYR59 ASP99 ASN101 GLY102 LYS103 ASP104 GLY105 GLY106 C: THR31 TYR34 TYR36 SER95 TRP96 GLU97 ILE98 TYR100 A: HIS195 LYS196 SER197 SER198 GLU341 GLN342 SER344 CYS345 TYR346 ASN347 ASN348 ASN349 PHE350 ASN352 ASN354 THR449 GLN451 LYS452 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
