Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 974 |
| PDBID: | 4TVS |
| Chains: | a_A |
| Organism: | Homo sapiens, Vicugna pacos |
| Method: | XRD |
| Resolution (Å): | 1.60 |
| Reference: | 10.7554/eLife.03239 |
| Antibody | |
| Antibody: | BS1 VHH |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Torsin-1A-interacting protein 1 |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Chain: a
Mutation: NULL
| >4TVS_A|Chain A, B|Torsin-1A-interacting protein 1|Homo sapiens (9606) GPGSTPEVETTAVQEFQNQMNQLKNKYQGQDEKLWKRSQTFLEKHLNSSHPRSQPAILLLTAARDAEEALRCLSEQIADAYSSFRSVRAIRIDGTDKATQDSDTVKLEVDQELSNGFKNGQNAAVVHRFESFPAGSTLIFYKYCDHENAAFKDVALVLTVLLEEETLGTSLGLKEVEEKVRDFLKVKFTNSNTPNSYNHMDPDKLNGLWSRISHLVLPVQPENALKRGICL |
Antigen
Chain: A
Mutation: NULL
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| a: ARG28 SER32 TYR33 THR100 PHE101 THR102 PRO103 TRP107 TYR108 TYR109 THR110 ARG111 SER113 SER114 ASP116 A: SER405 GLN406 TYR493 LYS494 ASP497 HIS498 GLU499 ASN500 PRO554 ASP555 LYS556 GLY559 SER562 ARG563 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
