Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 97 |
| PDBID: | 1MHP |
| Chains: | HL_A |
| Organism: | Rattus norvegicus, Mus musculus |
| Method: | XRD |
| Resolution (Å): | 2.80 |
| Reference: | 10.1016/s0022-2836(03)00203-1 |
| Antibody | |
| Antibody: | AQC2 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | integrin alpha 1, (RESIDUES 169-360) |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >1MHP_H|Chain B[auth H], E[auth X]|Fab fragment, heavy chain|Mus musculus (10090) EVQLVESGGGLVQPGGSLRLSCAASGFTFSRYTMSWVRQAPGKGLEWVATISGGGHTYYLDSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCTRGFGDGGYFDVWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPK |
Light Chain: L
Mutation: NULL
| >1MHP_L|Chain C[auth L], F[auth Y]|FAB FRAGMENT, light chain|Mus musculus (10090) IQLTQSPSSLSASVGDRVTITCSASSSVNHMFWYQQKPGKAPKPWIYLTSNLASGVPSRFSGSGSGTDYTLTISSLQPEDFATYYCQQWSGNPWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: A
Mutation: NULL
| >1MHP_A|Chain A, D[auth B]|integrin alpha 1, (RESIDUES 169-360)|Rattus norvegicus (10116) TQLDIVIVLDGSNSIYPWESVIAFLNDLLKRMDIGPKQTQVGIVQYGENVTHEFNLNKYSSTEEVLVAANKIVQRGGRQTMTALGIDTARKEAFTEARGARRGVKKVMVIVTDGESHDNYRLKQVIQDCEDENIQRFSIAILGHYNRGNLSTEKFVEEIKSIASEPTEKHFFNVSDELALVTIVKALGERIF |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| H: SER30 ARG31 THR33 TRP47 THR50 SER52 GLY53 GLY54 HIS56 TYR58 TYR59 GLY100 ASP101 L: SER28 VAL29 ASN30 HIS31 LEU49 SER66 GLY67 TRP90 SER91 ASN93 TRP95 A: SER156 ASN157 SER158 TYR160 GLU192 GLN218 ARG219 GLY220 GLY221 ARG222 GLN223 THR224 MET225 GLU259 SER260 HIS261 ASN263 TYR264 LYS298 ASP320 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
