Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 968 |
| PDBID: | 4TSB |
| Chains: | HL_A |
| Organism: | Gallus gallus, Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 1.95 |
| Reference: | Not available or To be published |
| Antibody | |
| Antibody: | 4TSB Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Lysozyme C |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >4TSB_H|Chain B[auth H]|FAb Heavy Chain|Homo sapiens (9606) QVQLVESGGGLVQPGGSLRLSCAASGFTVSSNYMSWVRQAPGKGLEWVSVIYSGGSTYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAREGRGDSFVYWGKGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSDCK |
Light Chain: L
Mutation: NULL
| >4TSB_L|Chain C[auth L]|FAb Light Chain|Homo sapiens (9606) QSVLAQPPSVSGAPGQRVSISCTGRSSNIGAGYDVHWYQQLPGKAPKLLIYGNTNRPSGVPVRFSGSMSGTSASLAITGLQAEDEADYYCQSYDRSLSGSVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS |
Antigen
Chain: A
Mutation: NULL
| >4TSB_A|Chain A|Lysozyme C|Gallus gallus (9031) KVFGRCELAAAMKRHGLDNYRGYSLGNWVCAAKFESNFNTQATNRNTDGSTDYGILQINSRWWCNDGRTPGSRNLCNIPCSALLSSDITASVNCAKKIVSDGNGMNAWVAWRNRCKGTDVQAWIRGCRL |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| H: TYR33 TYR52 GLY54 SER56 TYR58 GLU95 GLY96 ARG97 GLY98 ASP99 L: ALA29 GLY30 TYR31 ASP32 HIS34 SER90 TYR91 ARG93 A: ARG21 GLY22 TYR23 ASN27 GLY102 ASN103 GLY104 ASN106 ALA107 VAL109 TRP111 ARG112 ASN113 ARG114 LYS116 GLY117 THR118 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
