Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 95 |
| PDBID: | 1MEL |
| Chains: | B_M |
| Organism: | Camelus dromedarius, Gallus gallus |
| Method: | XRD |
| Resolution (Å): | 2.50 |
| Reference: | 10.1038/nsb0996-803 |
| Antibody | |
| Antibody: | cAb-Lys3 VHH |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Lysozyme C |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Chain: B
Mutation: NULL
| >1MEL_B|Chain A, B|VH SINGLE-DOMAIN ANTIBODY|Camelus dromedarius (9838) DVQLQASGGGSVQAGGSLRLSCAASGYTIGPYCMGWFRQAPGKEREGVAAINMGGGITYYADSVKGRFTISQDNAKNTVYLLMNSLEPEDTAIYYCAADSTIYASYYECGHGLSTGGYGYDSWGQGTQVTVSSGRYPYDVPDYGSGRA |
Antigen
Chain: M
Mutation: NULL
| >1MEL_M|Chain C[auth L], D[auth M]|LYSOZYME|Gallus gallus (9031) KVFGRCELAAAMKRHGLDNYRGYSLGNWVCAAKFESNFNTQATNRNTDGSTDYGILQINSRWWCNDGRTPGSRNLCNIPCSALLSSDITASVNCAKKIVSDGNGMNAWVAWRNRCKGTDVQAWIRGCRL |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| B: THR28 ILE29 GLY30 PRO31 TYR32 MET53 GLY54 GLY55 ILE57 ASN74 THR101 ILE102 TYR103 ALA104 SER105 TYR106 TYR107 GLU108 TYR118 GLY119 M: GLU35 ASN46 THR47 ASP48 ASP52 GLN57 ILE58 ASN59 ARG61 TRP62 TRP63 ARG73 LEU75 ILE98 ASP101 ASN103 ASN106 ALA107 TRP108 VAL109 ARG112 ASN113 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
