Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 922 |
| PDBID: | 4R8W |
| Chains: | HL_B |
| Organism: | Influenza A virus (A/Anhui/1-BALF_RG45/2013(H7N9)), Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 2.79 |
| Reference: | 10.1038/ncomms8708 |
| Antibody | |
| Antibody: | CT149 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | Navivumab(Preclinical) |
| Antigen | |
| Antigen: | Influenza A virus H7N9 hemagglutinin |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >4R8W_H|Chain C[auth H]|Heavy chain of neutralizing antibody CT149|Homo sapiens (9606) QVQLVQSGAEVKKPGASVKVSCKTSGYSFSTYGVSWVRQAPGQGPEWVGWISAYTGITDYAQKFQGRVTLTTDATTATAFLDLRSLRPDDTATYFCARDKVQGRVEVGSGGRHDYWGQGTLVIVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDK |
Light Chain: L
Mutation: NULL
| >4R8W_L|Chain D[auth L]|Light chain of neutralizing antibody CT149|Homo sapiens (9606) EVVLTQSPGTLALPPGERATLSCRASHRVGSTYIAWYQQKSGQAPRRLIYGASNRATDIPDRFSGSGSGTDFTLTIRRLEPEDSAVYYCQQFSVSPWTFGQGTRVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGECS |
Antigen
Chain: B
Mutation: NULL
| >4R8W_B|Chain B|Hemagglutinin|Influenza A virus (A/Anhui/1-BALF_RG45/2013(H7N9)) (1481988) GLFGAIAGFIENGWEGLIDGWYGFRHQNAQGEGTAADYKSTQSAIDQITGKLNRLIEKTNQQFELIDNEFNEVEKQIGNVINWTRDSITEVWSYNAELLVAMENQHTIDLADSEMDKLYERVKRQLRENAEEDGTGCFEIFHKCDDDCMASIRNNTYDHSKYREEAMQNRIQIDPVK |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| H: TYR54 THR55 ILE57 LYS100 VAL101 GLN102 GLY103 ARG104 VAL105 GLU106 VAL107 GLY108 L: GLY30 SER31 THR32 TYR33 GLY67 SER68 B: ASP340 GLY341 TRP342 TYR359 LYS360 THR362 GLN363 ILE366 ASP367 ILE369 THR370 GLY371 LEU373 ASN374 ILE377 GLU378 ASN381 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
