Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 910 |
| PDBID: | 4R2G |
| Chains: | NM_A |
| Organism: | Human immunodeficiency virus type 1 (JRCSF ISOLATE), Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 3.28 |
| Reference: | 10.1016/j.cell.2014.09.009 |
| Antibody | |
| Antibody: | PGT124 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | p53 DNA-binding domain |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: N
Mutation: NULL
| >4R2G_N|Chain D, G[auth J], J[auth N], M[auth Q]|PGT124 Heavy Chain|Homo sapiens (9606) QVQLQESGPGLVRPSETLSVTCIVSGGSISNYYWTWIRQSPGKGLEWIGYISDRETTTYNPSLNSRAVISRDTSKNQLSLQLRSVTTADTAIYFCATARRGQRIYGVVSFGEFFYYYYMDVWGKGTAVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCD |
Light Chain: M
Mutation: NULL
| >4R2G_M|Chain C, F[auth I], I[auth M], L[auth P]|PGT124 Light Chain|Homo sapiens (9606) SYVSPLSVALGETARISCGRQALGSRAVQWYQHKPGQAPILLIYNNQDRPSGIPERFSGTPDINFGTTATLTISGVEVGDEADYYCHMWDSRSGFSWSFGGATRLTVLSQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHKSYSCQVTHEGSTVEKTVAPTECS |
Antigen
Chain: A
Mutation: NULL
| >4R2G_A|Chain A, N[auth E], O[auth K], P[auth O]|Surface protein gp160|Human immunodeficiency virus type 1 group M subtype B (11688) DFNMWKNNMVEQMQEDVINLWDQSLKPCVKLTGGSVITQACPKVSFEPIPIHYCAPAGFAILKCNNKTFNGKGQCKNVSTVQCTHGIRPVVSTQLLLNGSLAEEKVVIRSDNFTDNAKTIIVQLNESVKINCTRPSNNTRPGEIIGDIRQAHCNISRAQWNNTLKQIVEKLREQFNNKTIVFTHSSGGDPEIVMHSFNCGGEFFYCNSTQLFNSTWNDTEKSSGTEGNDTIILPCRIKQIINMWQEVGKAMYAPPIKGQIRCSSNITGLLLTRDGGKNESEIEIFRPGGGDMRDNWRSELYKYKVVKIE |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| M: LEU28 GLY29 SER30 PHE67 SER93 ARG94 A: ILE323 GLY324 ASP325 ILE326 ARG327 GLN328 HIS330 ILE415 PRO417 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
