Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 91 |
| PDBID: | 1KXV |
| Chains: | C_A |
| Organism: | Sus scrofa, Camelus dromedarius |
| Method: | XRD |
| Resolution (Å): | 1.60 |
| Reference: | 10.1074/jbc.M202327200 |
| Antibody | |
| Antibody: | CABAMD10 VHH |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | porcine pancreatic alpha-amylase |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Chain: C
Mutation: NULL
| >1KXV_C|Chain C, D|CAMELID VHH DOMAIN CAB10|Camelus dromedarius (9838) QVQLVESGGGTVPAGGSLRLSCAASGNTLCTYDMSWYRRAPGKGRDFVSGIDNDGTTTYVDSVAGRFTISQGNAKNTAYLQMDSLKPDDTAMYYCKPSLRYGLPGCPIIPWGQGTQVTVSS |
Antigen
Chain: A
Mutation: NULL
| >1KXV_A|Chain A, B|ALPHA-AMYLASE, PANCREATIC|Sus scrofa (9823) QYAPQTQSGRTSIVHLFEWRWVDIALECERYLGPKGFGGVQVSPPNENIVVTNPSRPWWERYQPVSYKLCTRSGNENEFRDMVTRCNNVGVRIYVDAVINHMCGSGAAAGTGTTCGSYCNPGSREFPAVPYSAWDFNDGKCKTASGGIESYNDPYQVRDCQLVGLLDLALEKDYVRSMIADYLNKLIDIGVAGFRIDASKHMWPGDIKAVLDKLHNLNTNWFPAGSRPFIFQEVIDLGGEAIKSSEYFGNGRVTEFKYGAKLGTVVRKWSGEKMSYLKNWGEGWGFMPSDRALVFVDNHDNQRGHGAGGSSILTFWDARLYKIAVGFMLAHPYGFTRVMSSYRWARNFVNGEDVNDWIGPPNNNGVIKEVTINADTTCGNDWVCEHRWREIRNMVWFRNVVDGQPFANWWDNGSNQVAFGRGNRGFIVFNNDDWQLSSTLQTGLPGGTYCDVISGDKVGNSCTGIKVYVSSDGTAQFSISNSAEDPFIAIHAESKL |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| C: ASP33 SER35 TYR37 ASP46 PHE47 ASP52 ASP54 THR56 THR57 THR58 TYR59 VAL60 ASP61 LYS96 SER98 LEU99 ARG100 TYR101 GLY102 LEU103 CYS106 ILE108 TRP111 A: GLN1 TYR2 LYS140 ASP153 PRO154 TYR155 ARG158 GLU171 ARG176 TRP203 PRO204 GLY205 ASP206 LYS208 ASP212 ALA241 LYS243 SER245 GLU246 PHE248 GLY249 ASN250 GLU282 GLY283 GLY285 PHE286 MET287 PRO288 SER289 ASP290 ARG291 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
