Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 903 |
| PDBID: | 4QNP |
| Chains: | EF_A |
| Organism: | Influenza A virus, Mus musculus |
| Method: | XRD |
| Resolution (Å): | 2.80 |
| Reference: | 10.1038/ncomms7114 |
| Antibody | |
| Antibody: | CD6 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Influenza A virus neuraminidase |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: E
Mutation: NULL
| >4QNP_E|Chain D[auth E], F[auth H]|neutralizing antibody, heavy chain|Mus musculus (10090) QVKLQESGGGLVQPKGSLKLSCAASGFTFNTYAMNWVRQAPGKGLEWVARIRSKSNNYATFYADSVKDRFTISRDDSQSMLYLQMHNLKTDDTAMYYCVRPSIYYYASGYLDVWGAGTTVTVSSAKTTAPSVYPLAPVCGDTTGSSVTLGCLVKGYFPEPVTLTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVTSSTWPSQSITCNVAHPASSTKVDKKIEPR |
Light Chain: F
Mutation: NULL
| >4QNP_F|Chain C[auth F], E[auth L]|neutralizing antibody, light chain|Mus musculus (10090) QIVLSQSPAILSASPGEKVTMTCRTSSSVSYMHWYQQKPGSSPKPWIYATSNLASGVPFRFSGSGSGTSYSLTISRVEAEDAATYYCQQWNSNPPTFGGGTKLEIKRADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNRNE |
Antigen
Chain: A
Mutation: NULL
| >4QNP_A|Chain A, B|Neuraminidase|Influenza A virus (11320) SVKLAGNSSLCPVSGWAIYSKDNSVRIGSKGDVFVIREPFISCSPLECRTFFLTQGALLNDKHSNGTIKDRSPYRTLMSCPIGEVPSPYNSRFESVAWSASACHDGINWLTIGISGPDNGAVAVLKYNGIITDTIKSWRNNILRTQESECACVNGSCFTVMTDGPSNGQASYKIFRIEKGKIVKSVEMNAPNYHYEECSCYPDSSEITCVCRDNWHGSNRPWVSFNQNLEYQIGYICSGIFGDNPRPNDKTGSCGPVSSNGANGVKGFSFKYGNGVWIGRTKSISSRNGFEMIWDPNGWTGTDNNFSIKQDIVGINEWSGYSGSFVQHPELTGLDCIRPCFWVELIRGRPKENTIWTSGSSISFCGVNSDTVGWSWPDGAELPFTI |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| F: SER30 TYR31 TYR48 ALA49 SER51 ASN52 LEU53 ALA54 SER55 GLY56 VAL57 PHE59 SER62 E: TYR104 TYR105 TYR106 A: ASP214 THR215 ILE216 LYS217 TRP219 ARG220 ASN221 PRO246 GLN250 ALA251 SER252 LYS254 LYS262 ILE263 VAL264 LYS265 SER266 VAL267 GLU268 ASN270 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
