Details
Structure visualisation
Entry information
Sequence information
Antibody
Heavy Chain: B
Mutation: NULL
| >4QHU_B|Chain B, D[auth H]|Fab6785 heavy chain|Homo sapiens (9606) QVQLLESGGGLVQPGGSLRLSCAASGFTFSSYAMSWVRQAPGKGLEWVSTISLTSGFTYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARQLTLDVWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCHHHHHH |
Light Chain: A
Mutation: NULL
| >4QHU_A|Chain A, C[auth L]|Fab6785 light chain|Homo sapiens (9606) QSVLTQPPSVSVAPGQTARISCSGDNLGDKYANWYQQKPGQAPVLVIYDDIDRPSGIPERFSGSNSGNTATLTISGTQAEDEADYYCGSYDFFLGMIVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS |
Antigen
Chain: D
Mutation: NULL
| >4QHU_D|Chain E[auth C], F[auth D]|Interleukin-17A|Homo sapiens (9606) GITIPRNPGCPNSEDKNFPRTVMVNLNIHNRNTNTNPKRSSDYYNRSTSPWNLHRNEDPERYPSVIWEAQCRHLGCINADGNVDYHMNSVPIQQEILVLRREPPHCPNSFRLEKILVSVGCTCVTPIVHHVQ |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| A: ASN26 ASP29 TYR31 TYR48 ASP49 ILE51 ASP52 ASN68 TYR90 PHE92 PHE93 GLY95 B: ALA33 THR50 SER52 LEU53 THR54 GLY56 PHE57 TYR59 GLN99 LEU100 THR101 D: LEU26 ILE28 HIS29 SER40 ARG55 GLU57 ASP58 PRO59 GLU60 ARG61 TYR62 PRO63 SER64 VAL65 TRP67 LEU99 ARG101 GLU102 PRO103 PRO104 ASN108 PHE110 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
