Details
Structure visualisation
Entry information
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >4QHU_H|Chain B, D[auth H]|Fab6785 heavy chain|Homo sapiens (9606) QVQLLESGGGLVQPGGSLRLSCAASGFTFSSYAMSWVRQAPGKGLEWVSTISLTSGFTYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARQLTLDVWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCHHHHHH |
Light Chain: L
Mutation: NULL
| >4QHU_L|Chain A, C[auth L]|Fab6785 light chain|Homo sapiens (9606) QSVLTQPPSVSVAPGQTARISCSGDNLGDKYANWYQQKPGQAPVLVIYDDIDRPSGIPERFSGSNSGNTATLTISGTQAEDEADYYCGSYDFFLGMIVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS |
Antigen
Chain: C
Mutation: NULL
| >4QHU_C|Chain E[auth C], F[auth D]|Interleukin-17A|Homo sapiens (9606) GITIPRNPGCPNSEDKNFPRTVMVNLNIHNRNTNTNPKRSSDYYNRSTSPWNLHRNEDPERYPSVIWEAQCRHLGCINADGNVDYHMNSVPIQQEILVLRREPPHCPNSFRLEKILVSVGCTCVTPIVHHVQ |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| L: ASN26 GLY28 ASP29 LYS30 TYR31 TYR48 ASP49 ASP50 ILE51 ASP52 ASN65 GLY67 TYR90 PHE92 PHE93 LEU94 GLY95 H: ALA33 SER52 LEU53 THR54 GLY56 PHE57 TYR59 GLN99 LEU100 THR101 C: LEU26 ASN27 ILE28 ASN30 THR35 ASN36 LYS38 ARG39 SER40 ARG55 GLU57 ASP58 PRO59 GLU60 ARG61 TYR62 SER64 VAL65 TRP67 LEU99 ARG100 ARG101 GLU102 PRO103 PRO104 PHE110 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
