Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 897 |
| PDBID: | 4QCI |
| Chains: | BA_D |
| Organism: | Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 2.30 |
| Reference: | 10.1021/bi5015425 |
| Antibody | |
| Antibody: | MOR8457 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Platelet-derived growth factor subunit B |
| Antigen mutation: | No |
| Durg Target: | P01127 |
Sequence information
Antibody
Heavy Chain: B
Mutation: NULL
| >4QCI_B|Chain B, E[auth H]|anti-PDGF-BB antibody - Heavy chain|Homo sapiens (9606) EVQLVESGGGLVQPGGSLRLSCAASGFTFSSYAMSWVRQAPGKGLEWVSYISDDGSLKYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARHPYWYGGQLDLWGQGTLVTVSSAKTTPPSVYPLAPGSAAQTNSMVTLGCLVKGYFPEPVTVTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVPSSTWPSETVTCNVAHPASSTKVDKKIVPRDCG |
Light Chain: A
Mutation: NULL
| >4QCI_A|Chain A, F[auth L]|anti-PDGF-BB antibody - Light Chain|Homo sapiens (9606) SYELTQPPSVSVAPGQTARISCSGDSLGSYFVHWYQQKPGQAPVLVIYDDSNRPSGIPERFSGSNSGNTATLTISGTQAEDEADYYCSAFTHNSDVFGGGTKLTVLPKSTPTLTVFPPSSEELKENKATLVCLISNFSPSGVTVAWKANGTPITQGVDTSNPTKEGNKFMASSFLHLTSDQWRSHNSFTCQVTHEGDTVEKSLSPAECL |
Antigen
Chain: D
Mutation: NULL
| >4QCI_D|Chain C, D|Platelet-derived growth factor subunit B|Homo sapiens (9606) MSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVT |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| A: GLY28 SER29 TYR30 PHE31 ASP49 ASP50 ASN65 PHE90 THR91 HIS92 ASN93 SER94 VAL96 B: TRP47 TYR50 LEU57 TYR59 TYR60 ASP62 LYS65 TRP102 TYR103 GLY104 GLY105 D: LEU38 VAL39 TRP40 PRO42 GLN71 ARG73 ILE75 GLU76 ILE77 ARG79 LYS80 LYS81 PRO82 ILE83 PHE84 LYS85 LYS86 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
