Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 872 |
| PDBID: | 4OKV |
| Chains: | AB_F |
| Organism: | Mus musculus, Anopheles stephensi |
| Method: | XRD |
| Resolution (Å): | 1.80 |
| Reference: | Not available or To be published |
| Antibody | |
| Antibody: | 8H7 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Anti-platelet aggregation protein |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: A
Mutation: NULL
| >4OKV_A|Chain A, C|heavy chain of 8H7 mAb|Mus musculus (10090) QVQLQQPGAELVRPGASVKLSCKASGYTFTSYWMNWVKQRPGQGLEWIGLIDPSDSETHYNQMFKDKATLTVDKSSSTAYMQLSSLTSEDSAVYYCARGGTYWGQGTTLTVSAAKTTPPSVYPLAPGSAAQTNSMVTLGCLVKGYFPEPVTVTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVPSSTWPSETVTCNVAHPASSTKVDKKIVPRDC |
Light Chain: B
Mutation: NULL
| >4OKV_B|Chain B, D|light chain of 8H7 mAb|Mus musculus (10090) DVVMTQTPLTLSVTIGQPASIACKSSQSLLDSDGKTYLNWLLQRPGQSPKRLIYLVSKLDSGVPDRFTGSGSGTDFTLKISRVEAEDLGVYYCWQGTHFPYTFGGGTKLEIKRADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNRNA |
Antigen
Chain: F
Mutation: NULL
| >4OKV_F|Chain E, F|Anti-platelet aggregation protein|Anopheles stephensi (30069) KYSKIKECFDSLADDVKSLVEKSETSYEECSKDKNNPHCGSEGTRELDEGLIEREQKLSDCIVEKR |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| A: TYR27 THR28 THR30 SER31 TYR32 TRP33 ASP52 SER54 ASP55 ARG98 GLY99 THR101 TYR102 B: ASP31 ASP33 LYS35 TYR37 ASN39 ARG51 TYR54 LEU55 LYS58 ASP60 SER61 TRP94 GLY96 THR97 PHE99 TYR101 F: LYS222 SER226 GLU228 GLU229 CYS230 SER231 LYS232 ASP233 LYS234 ASN235 ASN236 CYS239 GLU242 ARG245 GLU246 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
