Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 867 |
| PDBID: | 4OD2 |
| Chains: | BA_S |
| Organism: | Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 3.20 |
| Reference: | 10.1038/sj.cdd.4402306 |
| Antibody | |
| Antibody: | drozitumab Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | Drozitumab(Phase-II) |
| Antigen | |
| Antigen: | Tumor necrosis factor receptor superfamily member 10B (DR5) |
| Antigen mutation: | No |
| Durg Target: | O14763 |
Sequence information
Antibody
Heavy Chain: B
Mutation: NULL
| >4OD2_B|Chain B|Fab fragment of drozitumab, heavy chain|Homo sapiens (9606) EVQLVQSGGGVERPGGSLRLSCAASGFTFDDYAMSWVRQAPGKGLEWVSGINWQGGSTGYADSVKGRVTISRDNAKNSLYLQMNSLRAEDTAVYYCAKILGAGRGWYFDYWGKGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTAAP |
Light Chain: A
Mutation: NULL
| >4OD2_A|Chain A|Fab fragment of drozitumab, light chain|Homo sapiens (9606) SELTQDPAVSVALGQTVRITCSGDSLRSYYASWYQQKPGQAPVLVIYGANNRPSGIPDRFSGSSSGNTASLTITGAQAEDEADYYCNSADSSGNHVVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHKSYSCQVTHEGSTVEKTVAPTECS |
Antigen
Chain: S
Mutation: NULL
| >4OD2_S|Chain C[auth S]|Tumor necrosis factor receptor superfamily member 10B|Homo sapiens (9606) RSSPSEGLCPPGHHISEDGRDCISCKYGQDYSTHWNDLLFCLRCTRCDSGEVELSPCTTTRNTVCQCEEGTFREEDSPEMCRKCRTGCPRGMVKVGDCTPWSDIECVHKES |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| A: LEU26 ARG27 SER28 TYR29 TYR30 ALA31 TYR47 ALA49 ASN51 SER64 SER65 GLY66 SER91 SER92 GLY93 B: ASP30 ASP31 ASN52 TRP53 GLN54 GLY56 SER57 ILE99 LEU100 GLY101 ALA102 GLY103 ARG104 GLY105 TRP106 TYR107 S: LYS45 GLY47 GLN48 ARG62 CYS63 THR64 ARG65 CYS66 ASP67 SER68 GLY69 GLU70 VAL71 GLU72 THR82 GLU87 GLU88 GLY89 THR90 MET99 CYS100 LYS102 CYS103 THR105 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
