Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 866 |
| PDBID: | 4O9H |
| Chains: | HL_A |
| Organism: | Homo sapiens, Lama glama |
| Method: | XRD |
| Resolution (Å): | 2.42 |
| Reference: | Not available or To be published |
| Antibody | |
| Antibody: | Camelid 61H7 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Interleukin-6 |
| Antigen mutation: | No |
| Durg Target: | P05231 |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >4O9H_H|Chain B[auth H]|Heavy Chain of the Camelid Fab fragment 61H7|Lama glama (9844) EVQLVESGGGLVQPGGSLRLSCAASGFTFSSYRMYWVRQPPGKGLEWVSAISAGGGSTYYGDSVKGRFTISRDNAKNTVYLQMNSLKPEDTAVYYCANRAGWGMGDYWGQGTQVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDK |
Light Chain: L
Mutation: NULL
| >4O9H_L|Chain C[auth L]|Light Chain of the Camelid Fab fragment 61H7|Lama glama (9844) QTVVTQEPSLSVSPGGTVTLTCGLSSGSVTASNYPGWFQQTPGQAPRALIYSTNDRHSGVPSRFSGSISGNKAALTITGAQPEDEADYYCALDIGDITEFGGGTHLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS |
Antigen
Chain: A
Mutation: NULL
| >4O9H_A|Chain A|Interleukin-6|Homo sapiens (9606) MAPVPPGEDSKDVAAPHRQPLTSSERIDKQIRYILDGISALRKETCNKSNMCESSKEALAENNLNLPKMAEKDGCFQSGFNEETCLVKIITGLLEFEVYLEYLQNRFESSEEQARAVQMSTKVLIQFLQKKAKNLDAITTPDPTTNASLLTKLQAQNQWLQDMTTHLILRSFKEFLQSSLRALRQM |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| H: THR28 SER30 SER31 TYR32 ARG33 SER52 ALA53 GLY54 GLY56 SER57 TYR59 ARG99 ALA100 GLY101 TRP102 L: LEU24 SER28 THR30 ALA31 SER32 ASN33 TYR34 ASP93 ILE94 GLY95 ASP96 A: THR20 SER21 SER22 GLU23 ASP26 LYS27 ARG30 CYS73 PHE74 GLN75 SER76 PHE78 GLU80 LYS129 LEU178 ARG179 ALA180 ARG182 GLN183 MET184 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
