Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 860 |
| PDBID: | 4O5I |
| Chains: | MN_A |
| Organism: | Influenza A virus (A/Singapore/H2011.447/2011(H3N2)), Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 6.50 |
| Reference: | 10.1038/ncomms4614 |
| Antibody | |
| Antibody: | F045-092 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Influenza A virus H3N2 hemagglutinin |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: M
Mutation: NULL
| >4O5I_M|Chain M, O, Q, S, U, W|Fab F045-092 heavy chain|Homo sapiens (9606) EVQLVESGAEVKKPGSSVKVSCRASGTFYKYAINWVRQAPGQGLEWMGGIIPFFGTTNYAQKFQGRLTITADGSTNTAYMQLDSLRSEDTAVYYCAGPSITESHYCLDCAAKDYYYGLDVWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCHHHHHH |
Light Chain: N
Mutation: NULL
| >4O5I_N|Chain N, P, R, T, V, X|Fab F045-092 light chain|Homo sapiens (9606) QSVLTQPPSASGTPGQSVTISCSGSRSNIGGNTVNWYQHLPGMAPKLLIYSSNQRSSGVPDRFSGSKSGTSASLAISGLQSEDDADYYCASWDDSLNGVVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS |
Antigen
Chain: A
Mutation: NULL
| >4O5I_A|Chain A, C, E, G, I, K|Hemagglutinin HA1 chain|Influenza A virus (1331560) ADPGATLCLGHHAVPNGTIVKTITNDQIEVTNATELVQNSSIGEICDSPHQILDGENCTLIDALLGDPQCDGFQNKKWDLFVERSKAYSNCYPYDVPDYASLRSLVASSGTLEFNNESFNWTGVTQNGTSSACIRRSNNSFFSRLNWLTHLNFKYPALNVTMPNNEQFDKLYIWGVHHPGTDKDQIFLYAQSSGRITVSTKRSQQAVIPNIGSRPRIRNIPSRISIYWTIVKPGDILLINSTGNLIAPRGYFKIRSGKSSIMRSDAPIGKCNSECITPNGSIPNDKPFQNVNRITYGACPRYVKQSTLKLATGMRNVPEKQTR |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| M: THR27 TYR29 LYS30 PHE53 PHE54 GLY73 SER74 ASN76 A: TYR98 THR131 GLN132 ASN133 GLY134 THR135 SER136 SER137 ASN144 ASN145 SER146 TRP153 THR155 HIS156 LEU157 ASN158 PHE159 ASP190 PHE193 LEU194 ILE226 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
