Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 839 |
| PDBID: | 4N1E |
| Chains: | F_K |
| Organism: | Homo sapiens, Gallus gallus |
| Method: | XRD |
| Resolution (Å): | 2.23 |
| Reference: | 10.1073/pnas.1613477114 |
| Antibody | |
| Antibody: | VL5 VL-sdAb |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Lysozyme C |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Chain: F
Mutation: NULL
| >4N1E_F|Chain A, B, C, D, E, F, G, H|immunoglobulin variable light chain domain|Homo sapiens (9606) DIQMTQSPSSLSASVGDRVTITCRASQDIAAALNWYQQKPGKAPKLLIYASSYLQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQDGYYPATFGQGTKVEIKRA |
Antigen
Chain: K
Mutation: NULL
| >4N1E_K|Chain I, J, K, L|Lysozyme C|Gallus gallus (9031) KVFGRCELAAAMKRHGLDNYRGYSLGNWVCAAKFESNFNTQATNRNTDGSTDYGILQINSRWWCNDGRTPGSRNLCNIPCSALLSSDITASVNCAKKIVSDGNGMNAWVAWRNRCKGTDVQAWIRGCRL |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| F: ASP28 ILE29 ALA30 ALA31 ALA32 TYR49 ALA50 TYR53 ASP91 GLY92 TYR93 TYR94 K: VAL2 LYS33 PHE34 SER36 ASN37 PHE38 ASN39 ALA42 ARG114 ASP119 ALA122 TRP123 ARG125 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
