Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 828 |
| PDBID: | 4M7L |
| Chains: | HL_T |
| Organism: | Homo sapiens, Mus musculus |
| Method: | XRD |
| Resolution (Å): | 3.40 |
| Reference: | Not available or To be published |
| Antibody | |
| Antibody: | 10H10 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Tissue factor |
| Antigen mutation: | No |
| Durg Target: | P13726 |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >4M7L_H|Chain C[auth H]|10H10 heavy chain|Mus musculus (10090) QVHLQQSGAELMKPGASVKISCKASGYTFITYWIEWVKQRPGHGLEWIGDILPGSGSTNYNENFKGKATFTADSSSNTAYMQLSSLTSEDSAVYYCARSGYYGNSGFAYWGQGTLVTVSAASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCHHHHHH |
Light Chain: L
Mutation: NULL
| >4M7L_L|Chain B[auth L]|10H10 light chain|Mus musculus (10090) DIVMTQSPSSLTVTAGEKVTMSCKSSQSLLSSGNQKNYLTWYQQIPGQPPKLLIYWASTRESGVPDRFTGSGSGTDFTLTINSVQAEDLAVYYCQNDYTYPLTFGAGTKLELKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: T
Mutation: NULL
| >4M7L_T|Chain A[auth T]|Tissue factor|Homo sapiens (9606) NTVAAYNLTWKSTNFKTILEWEPKPVNQVYTVQISTKSGDWKSKCFYTTDTECDLTDEIVKDVKQTYLARVFSYPAGNVESTGSAGEPLYENSPEFTPYLETNLGQPTIQSFEQVGTKVNVTVEDERTLVRRNNTFLSLRDVFGKDLIYTLYYWKSSSSGKKTAKTNTNEFLIDVDKGENYCFSVQAVIPSRTVNRKSTDSPVECMGQEHHHHHH |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| L: SER31 SER32 GLY33 ASN34 LYS36 TYR38 TYR55 TRP56 THR59 ARG60 ASP97 TYR98 THR99 TYR100 LEU102 H: TYR27 THR28 ILE30 THR31 TYR32 TRP33 LEU52 GLY54 SER55 SER57 SER99 GLY100 TYR101 TYR102 GLY103 ASN104 T: LYS65 ASP66 VAL67 LYS68 GLN69 THR70 THR101 TYR103 LEU104 GLU105 GLN114 THR126 ASP129 VAL134 ARG135 ARG136 LEU141 ARG144 ASP145 VAL146 PHE147 GLY148 LYS149 ASP150 ASN171 THR172 ASN173 GLU174 SER195 ARG196 THR197 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
