Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 80 |
| PDBID: | 1KEN |
| Chains: | HL_A |
| Organism: | Influenza A virus (A/X-31(H3N2)), Mus musculus |
| Method: | XRD |
| Resolution (Å): | 3.50 |
| Reference: | 10.1006/viro.2001.1320 |
| Antibody | |
| Antibody: | 1KEN Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Influenza A virus H3N2 hemagglutinin |
| Antigen mutation: | No |
| Durg Target: | P03437 |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >1KEN_H|Chain H, J[auth T]|influenza virus infectivity neutralizing antibody (heavy chain)|Mus musculus (10090) DVHLQESGPGLVKPSQSLSLTCYVTGYSITSGYYWTWIRQFPGNKLEWMGYISYDGSNNYNPSLKNRISITRDTSKNQFFLKLNSVTAEDTASYYCAAFYYDYDFFFDYWGQGTTLTVSSAKTTPPSVYPLAPGSAAQTNSMVTLGCLVKGYFPEPVTVTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVPSSTWPSETVTCNVAHPASSTKVDKKIVPRD |
Light Chain: L
Mutation: NULL
| >1KEN_L|Chain G[auth L], I[auth U]|influenza virus infectivity neutralizing antibody (light chain)|Mus musculus (10090) QIVLTQSPAIMSASPGEKVTLTCSASSTITSSFLYWYQQKPGSSPKLWIYSTSNLASGVPARFSGSGSGTSYSLTISSLEAEDGASYFCHQWETFPRTFGGGTKLEIKRADAAPTVSIFPPSKIQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNRN |
Antigen
Chain: A
Mutation: NULL
| >1KEN_A|Chain A, C, E|hemagglutinin HA1|Influenza A virus (A/X-31(H3N2)) (132504) QDLPGNDNSTATLCLGHHAVPNGTLVKTITDDQIEVTNATELVQSSSTGKICNNPHRILDGIDCTLIDALLGDPHCDVFQNETWDLFVERSKAFSNCYPYDVPDYASLRSLVASSGTLEFITEGFTWTGVTQNGGSNACKRGPGSGFFSRLNWLTKSGSTYPVLNVTMPNNDNFDKLYIWGIHHPSTNQEQTSLYVQASGRVTVSTRRSQQTIIPNIGSRPWVRGLSSRISIYWTIVKPGDVLVINSNGNLIAPRGYFKMRTGKSSIMRSDAPIDTCISECITPNGSIPNDKPFQNVNKITYGACPKYVKQNTLKLATGMRNVPEKQT |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| L: THR30 SER31 SER32 TYR50 ASN54 LEU55 SER57 GLY58 VAL59 PRO60 ALA61 H: TYR27 TYR33 TYR100 TYR101 ASP102 TYR103 ASP104 PHE105 PHE107 TYR109 A: GLY135 SER136 ASN137 TRP153 LYS156 GLY158 SER159 SER186 THR187 GLN189 GLU190 THR192 SER193 LEU194 SER219 TRP222 GLY225 LEU226 SER227 SER228 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
