Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 799 |
| PDBID: | 4KXZ |
| Chains: | HL_A |
| Organism: | Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 2.83 |
| Reference: | 10.1002/pro.2548 |
| Antibody | |
| Antibody: | GC1008 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Transforming growth factor beta-2 |
| Antigen mutation: | No |
| Durg Target: | P61812 |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >4KXZ_H|Chain E[auth H], F[auth J], G[auth N], H[auth Q]|GC1008 Heavy Chain|Homo sapiens (9606) QVQLVQSGAEVKKPGSSVKVSCKASGYTFSSNVISWVRQAPGQGLEWMGGVIPIVDIANYAQRFKGRVTITADESTSTTYMELSSLRSEDTAVYYCASTLGLVLDAMDYWGQGTLVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVHHHHHH |
Light Chain: L
Mutation: NULL
| >4KXZ_L|Chain I, J[auth L], K[auth M], L[auth P]|GC1008 Light Chain|Homo sapiens (9606) ETVLTQSPGTLSLSPGERATLSCRASQSLGSSYLAWYQQKPGQAPRLLIYGASSRAPGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYADSPITFGQGTRLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: A
Mutation: NULL
| >4KXZ_A|Chain A, B, C[auth D], D[auth E]|Transforming growth factor beta-2|Homo sapiens (9606) ALDAAYCFRNVQDNCCLRPLYIDFKRDLGWKWIHEPKGYNANFCAGACPYLWSSDTQHSRVLSLYNTINPEASASPCCVSQDLEPLTILYYIGKTPKIEQLSNMIVKSCKCS |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| H: SER30 SER31 ASN32 VAL33 TRP47 ILE52 PRO53 ILE54 VAL55 ILE57 ASN59 LEU100 GLY101 LEU102 VAL103 LEU104 L: GLN27 SER28 TYR33 TYR92 ALA93 ASP94 SER95 A: LEU28 GLY29 TRP30 LYS31 TRP32 ILE33 TYR90 TYR91 ILE92 GLY93 LYS94 THR95 LYS97 GLU99 LEU101 MET104 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
