Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 792 |
| PDBID: | 4KUC |
| Chains: | DH_A |
| Organism: | Ricinus communis, Mus musculus |
| Method: | XRD |
| Resolution (Å): | 2.79 |
| Reference: | Not available or To be published |
| Antibody | |
| Antibody: | mAb6c2 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Ricin-A |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: D
Mutation: NULL
| >4KUC_D|Chain B[auth D], E|mAb6c2 fab-Heavy chain|Mus musculus (10090) METDTLLLWVLLLWVPGSTGDIVLTQSPASLAVSLGQRATISYRASKSVSYMHWNQQKPGQPPRLLIYLGSNLESGVGARFSGSGSGTDFTLNIHPVEEEDAATYYCQHKREYPPTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVGNLQGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Light Chain: H
Mutation: NULL
| >4KUC_H|Chain C[auth F], F[auth H]|mAb6c2 fab-Light chain|Mus musculus (10090) MGWSSIILFLVATASGVHSQVQLQQPGSELVRPGASVKLSCKASGYTFTSYWINWVKQRPGQGLEWIGNIYPGSGRTNYDEKFKNKATLTVDTSSSTVYIQVSSLTSEDAAVFYCVRWVYGNFDSALDYWGQGTSVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWGSGASGVHTFPAVLQSSGLYSLSSVVTVPSSSLGQTYICNVNHKPSNTKVDKKVEP |
Antigen
Chain: A
Mutation: NULL
| >4KUC_A|Chain A, D[auth I]|Ricin|Ricinus communis (3988) IFPKQYPIINFTTAGATVQSYTNFIRAVRGRLTTGADVRHEIPVLPNRVGLPINQRFILVELSNHAELSVTLALDVTNAYVVGYRAGNSAYFFHPDNQEDAEAITHLFTDVQNRYTFAFGGNYDRLEQLAGNLRENIELGNGPLEEAISALYYYSTGGTQLPTLARSFIICIQMISEAARFQYIEGEMRTRIRYNRRSAPDPSVITLENSWGRLSTAIQESNQGAFASPIQLQRRNGSKFSVYDVSILIPIIALMVYRCAPPPSSQF |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| D: ILE22 LYS47 SER48 VAL49 SER50 GLY87 THR88 LYS110 ARG111 GLU112 TYR113 H: SER50 TYR51 TRP52 ASN69 TYR71 SER74 ARG76 THR77 ASN78 VAL119 TYR120 GLY121 ASN122 PHE123 A: VAL49 GLY50 LEU51 PRO52 ILE53 ARG56 PHE92 HIS94 PRO95 ASN97 GLN98 GLU99 ALA101 GLU102 ILE104 THR105 HIS106 THR109 ASP110 VAL111 GLN112 ASN113 ARG114 TYR115 THR116 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
