Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 78 |
| PDBID: | 1KB5 |
| Chains: | HL_A |
| Organism: | Mus musculus |
| Method: | XRD |
| Resolution (Å): | 2.50 |
| Reference: | 10.1093/emboj/16.14.4205 |
| Antibody | |
| Antibody: | anti-idiotype DESIRE-1 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | KB5-C20 T cell ANTIGEN RECEPTOR alpha |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >1KB5_H|Chain D[auth H]|ANTIBODY DESIRE-1|Mus musculus (10090) EVQLQQSGPELEKPGASVKISCKASGYSFTGYNMNWVKQSNGKSLEWIGNIDPYYGGISYNQKFKGRATLTVDKSSSTAYMQLKSLTSEDSAVYYCARSRTDLYYFDYWGQGTTLTVSSAKTTAPSVYPLAPVCGDTTGSSVTLGCLVKGYFPEPVTLTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVTSSTWPSQSITCNVAHPASSTKVDKKIEPR |
Light Chain: L
Mutation: NULL
| >1KB5_L|Chain C[auth L]|ANTIBODY DESIRE-1|Mus musculus (10090) DIQMTQSPASLSASVGETVTITCRASKNIYSYLAWYQQKQGKSPQLLVYNAKTLGEGVPSRFSGSGSGTQFSLKINSLQPEDFGSYYCQHHYGTPYTFGGGTKLEIKRADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNRNEC |
Antigen
Chain: A
Mutation: NULL
| >1KB5_A|Chain A|KB5-C20 T-CELL ANTIGEN RECEPTOR|Mus musculus (10090) QQVRQSPQSLTVWEGETAILNCSYEDSTFNYFPWYQQFPGEGPALLISIRSVSDKKEDGRFTIFFNKREKKLSLHITDSQPGDSATYFCAARYQGGRALIFGTGTTVSVSPGSAD |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| L: TYR32 ASN50 THR53 HIS91 TYR92 GLY93 H: SER28 THR30 GLY31 TYR32 TYR53 TYR54 ARG96 THR97 ASP98 LEU99 A: GLN1 GLN2 ARG4 GLU25 ASP26 TYR94 GLN95 GLY96 GLY97 ARG101 ALA103 ILE105 PHE106 THR108 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
