Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 77 |
| PDBID: | 1KB5 |
| Chains: | HL_B |
| Organism: | Mus musculus |
| Method: | XRD |
| Resolution (Å): | 2.50 |
| Reference: | 10.1093/emboj/16.14.4205 |
| Antibody | |
| Antibody: | anti-idiotype DESIRE-1 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | KB5-C20 T cell ANTIGEN RECEPTOR beta |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >1KB5_H|Chain D[auth H]|ANTIBODY DESIRE-1|Mus musculus (10090) EVQLQQSGPELEKPGASVKISCKASGYSFTGYNMNWVKQSNGKSLEWIGNIDPYYGGISYNQKFKGRATLTVDKSSSTAYMQLKSLTSEDSAVYYCARSRTDLYYFDYWGQGTTLTVSSAKTTAPSVYPLAPVCGDTTGSSVTLGCLVKGYFPEPVTLTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVTSSTWPSQSITCNVAHPASSTKVDKKIEPR |
Light Chain: L
Mutation: NULL
| >1KB5_L|Chain C[auth L]|ANTIBODY DESIRE-1|Mus musculus (10090) DIQMTQSPASLSASVGETVTITCRASKNIYSYLAWYQQKQGKSPQLLVYNAKTLGEGVPSRFSGSGSGTQFSLKINSLQPEDFGSYYCQHHYGTPYTFGGGTKLEIKRADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNRNEC |
Antigen
Chain: B
Mutation: NULL
| >1KB5_B|Chain B|KB5-C20 T-CELL ANTIGEN RECEPTOR|Mus musculus (10090) VTLLEQNPRWRLVPRGQAVNLRCILKNSQYPWMSWYQQDLQKQLQWLFTLRSPGDKEVKSLPGADYLATRVTDTELRLQVANMSQGRTLYCTCSAAPDWGASAETLYFGSGTRLTVL |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| L: LYS27 TYR30 SER31 TYR32 ASN50 TYR92 GLY93 THR94 H: ASN33 ASN50 TYR53 TYR54 GLY55 GLY56 ILE57 SER58 TYR59 GLN61 LYS64 THR97 ASP98 B: TRP31 GLN42 LEU43 GLN44 TRP45 THR48 ARG50 SER51 PRO52 ASP54 LYS55 GLU56 VAL57 LYS58 SER59 LEU60 PRO61 PRO98 TRP100 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
