Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 769 |
| PDBID: | 4J6R |
| Chains: | HL_G |
| Organism: | Human immunodeficiency virus 1, Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 1.64 |
| Reference: | 10.1126/science.1233989 |
| Antibody | |
| Antibody: | VRC23 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | HIV-1 gp120 |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >4J6R_H|Chain B[auth H]|HEAVY CHAIN OF ANTIBODY VRC23|Homo sapiens (9606) QVQFVQSGAEVKKPGASVRVSCEASGYSFTDYVLQWIRQAPGQRPEWMGWIKPERGAVSYAPQFQGRLTLTRDLYTETAYMHFKNLRSDDTAIYYCARGVRRDASWWLQFWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSC |
Light Chain: L
Mutation: NULL
| >4J6R_L|Chain C[auth L]|LIGHT CHAIN OF ANTIBODY VRC23|Homo sapiens (9606) EIVMTQSPVTVSVSRGGTATLSCRASQGVGSDVAWYQHKPGQTPRLLIYGASTRASGVPERFSGSGFHVDFTLSISGLQPEDVAIYYCQQYETFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: G
Mutation: NULL
| >4J6R_G|Chain A[auth G]|Envelope glycoprotein gp160|HUMAN IMMUNODEFICIENCY VIRUS 1 (11676) VWRDADTTLFCASDAKAYETEKHNVWATHACVPTDPNPQEIHLDNVTEKFNMWKNNMVEQMHTDIISLWDQSLKPCVKLTGGSAITQACPKVSFEPIPIHYCTPAGFAILKCKDEGFNGTGLCKNVSTVQCTHGIKPVVSTQLLLNGSLAEKNITIRSENITNNAKIIIVQLVQPVTIKCIRPNNGGSGSGGDIRQAHCNVTRSRWNKTLQEVAEKLRTYFGNKTIIFANSSGGDLEITTHSFNCGGEFFYCNTSGLFNSTWYVNSTWNDTDSTQESNDTITLPCRIKQIINMWQRAGQAMYAPPIPGVIKCESNITGLLLTRDGGKDNNVNETFRPGGGDMRDNWRSELYKYKVVEIE |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| H: THR30 VAL33 ARG44 PRO45 GLU46 TRP47 TRP50 GLU53 ARG54 GLY55 ALA56 VAL57 SER58 TYR59 ALA60 PRO61 GLN62 GLN64 ARG71 LEU73 TYR74 ARG98 ASP99 L: GLU1 ILE2 VAL3 GLN27 ASP32 TYR91 GLU96 THR97 PHE98 G: LYS97 LEU122 GLY124 GLY198 GLU275 ASN276 THR278 ASN279 ASN280 ALA281 LYS282 ILE283 LYS356 SER365 GLY366 GLY367 ASP368 GLU370 ILE371 ASN425 MET426 TRP427 ALA430 GLY431 GLN432 THR455 ARG456 ASP457 GLY458 GLY459 LYS460 ASP461 ASN462 ASN463 GLU466 ARG469 GLY472 GLY473 ASP474 MET475 ARG476 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
