Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 766 |
| PDBID: | 4IOS |
| Chains: | E_A |
| Organism: | Lactococcus phage TP901-1, Lama glama |
| Method: | XRD |
| Resolution (Å): | 2.40 |
| Reference: | 10.1073/pnas.1301336110 |
| Antibody | |
| Antibody: | 11 Nanobody |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | phage TP901-1 receptor binding proteins (RBPs) |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Chain: E
Mutation: NULL
| >4IOS_E|Chain D, E, F, G|Llama nanobody 11|Lama glama (9844) QVQLVESGGGLVQAGDSLRLSCAVSGRTFSSNVIGWFRQAPGKEREFVAAISWSTGSTYYGRSMKGRCAASRDNAKNTVALQLNSLKPEDTAVYYCAATLDWGKTLSDEYDYWGQGTQVTVSS |
Antigen
Chain: A
Mutation: NULL
| >4IOS_A|Chain A, B, C, H|BPP|Lactococcus phage TP901-1 (35345) TKSWSGELGGGIILSLRKKGTTVEYSIGGEISSSILANSNLVNRSVPNEFCPRNRCSLVGHMVGGWNAFHIDIPSSGVCQWFGPTASSGTPRGTGTYPID |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| E: PHE47 TYR59 TYR60 GLY61 ARG62 LYS65 TRP102 GLY103 LYS104 THR105 LEU106 GLU109 A: SER68 GLU70 GLY74 ILE76 SER78 SER89 ILE90 GLY91 GLY92 GLU93 ILE94 SER95 VAL126 SER150 SER151 GLY152 THR153 ARG155 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
