Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 759 |
| PDBID: | 4HWB |
| Chains: | HL_A |
| Organism: | Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 2.61 |
| Reference: | 10.1042/BJ20121819 |
| Antibody | |
| Antibody: | 10G5H6 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Interleukin-13 receptor subunit alpha-1 |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >4HWB_H|Chain B[auth H]|Fab heavy chain|Homo sapiens (9606) AEVQLVQSGAEVKKPGESLKISCKGSGYSFTSYWIGWVRQMPGKGLEWMGVIYPGDSYTRYSPSFQGQVTISADKSISTAYLQWSSLKASDTAMYYCARMPNWGSFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHL |
Light Chain: L
Mutation: NULL
| >4HWB_L|Chain C[auth L]|Fab light chain|Homo sapiens (9606) EVVLTQSPGTLSLSPGERATLSCRASQSISSSYLAWYQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYETFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGECA |
Antigen
Chain: A
Mutation: NULL
| >4HWB_A|Chain A|Interleukin-13 receptor subunit alpha-1|Homo sapiens (9606) TSRVKPDPPHIKNLSFHNDDLYVQWENPQNFISRCLFYEVEVNNSQTETHNVFYVQEAKCENPEFERNVENTSCFMVPGVLPDTLNTVRIRVKTNKLCYEDDKLWSNWSQEMSIHHHHHHHH |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| H: SER29 THR31 SER32 TYR33 TRP34 TRP48 VAL51 TYR53 GLY55 ASP56 SER57 TYR58 ARG60 THR70 LYS75 MET100 PRO101 ASN102 TRP103 L: VAL2 ILE29 SER30 SER31 SER32 TYR33 TYR50 GLY51 SER53 SER54 GLN91 TYR92 GLU93 A: VAL200 LYS201 PRO202 ASP203 ASN226 SER229 ARG230 LEU232 PHE233 GLU235 VAL248 PHE249 TYR250 GLN252 GLU253 LYS289 THR290 ASN291 LYS292 LEU293 CYS294 TYR295 GLU296 ASN303 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
