Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 757 |
| PDBID: | 4HEP |
| Chains: | G_A |
| Organism: | Lactococcus phage TP901-1, Lama glama |
| Method: | XRD |
| Resolution (Å): | 1.75 |
| Reference: | 10.1073/pnas.1301336110 |
| Antibody | |
| Antibody: | 17 VHH |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | BPP from Lactococcus phage TP901-1 |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Chain: G
Mutation: NULL
| >4HEP_G|Chain B[auth G]|vHH17 domain|Lama glama (9844) DVQLVESGGGLVQPGGSLRLSCEASGFSFDDYAIGWFRQAPGKEREGVSYISMSDGRTYVADSVTGRFTISSDNAKNTVYLQMNSLKLEDTAVYYCAAGRFVTFGSAWSFVGGGPYGIDYWGKGTLVTVSS |
Antigen
Chain: A
Mutation: NULL
| >4HEP_A|Chain A|BPP|Lactococcus phage TP901-1 (35345) MASIKKVYRGMKNGAETINDDLEAINSELTSGGNVVHKTGDETIAGKKTFTGNVEVNGSLTLPTKSWSGELGGGIILSLRKKGTTVEYSIGGEISSSILANSNLVNRSVPNEFCPRNRCSLVGHMVGGWNAFHIDIPSSGVCQWFGPTASSGTPRGTGTYPID |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| G: GLU44 TYR50 TYR59 VAL60 ASP62 THR65 VAL102 PHE104 GLY105 SER106 ALA107 TRP108 SER109 PHE110 VAL111 GLY112 GLY113 GLY114 PRO115 TYR116 GLY117 A: ALA2 SER3 ILE4 LYS5 LYS6 THR17 ASP20 ASP21 GLU23 ALA24 SER27 GLU28 SER31 GLY32 GLY33 ASN34 ASP41 GLU42 THR43 ALA45 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
