Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 750 |
| PDBID: | 4GXU |
| Chains: | MN_A |
| Organism: | Influenza A virus (A/Brevig Mission/1/1918(H1N1)), Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 3.29 |
| Reference: | 10.1371/journal.ppat.1003067 |
| Antibody | |
| Antibody: | 1F1 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Influenza A virus H1N1 hemagglutinin |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: M
Mutation: NULL
| >4GXU_M|Chain M, O, Q, S, U, W|Antibody 1F1, heavy chain|Homo sapiens (9606) QVQLVQSGGGVVQPRRSLRLSCAASGFTFSSYAMHWVRQAPGKGLEWVAVISYDGRNKYYADSVKGRFTVSRDNSKNTLYLQMNSLRAEDTSVYYCARELLMDYYDHIGYSPGPTWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDK |
Light Chain: N
Mutation: NULL
| >4GXU_N|Chain N, P, R, T, V, X|Antibody 1F1, light chain|Homo sapiens (9606) QPVLTQPPSASGSPGQRVTISCSGSSSNIGSYTVNWYQQLPGTAPKLLIYSLNQRPSGVPDRFSGSKSGTSASLAISGLQSEDEAVYYCAAWDDSLSAHVVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS |
Antigen
Chain: A
Mutation: NULL
| >4GXU_A|Chain A, C, E, G, I, K|Hemagglutinin HA1 chain|Influenza A virus (88776) ADPGDTICIGYHANNSTDTVDTVLEKNVTVTHSVNLLEDSHNGKLCKLKGIAPLQLGKCNIAGWLLGNPECDLLLTASSWSYIVETSNSENGTCYPGDFIDYEELREQLSSVSSFEKFEIFPKTSSWPNHETTKGVTAACSYAGASSFYRNLLWLTKKGSSYPKLSKSYVNNKGKEVLVLWGVHHPPTGTDQQSLYQNADAYVSVGSSKYNRRFTPEIAARPKVRDQAGRMNYYWTLLEPGDTITFEATGNLIAPWYAFALNRGSGSGIITSDAPVHDCNTKCQTPHGAINSSLPFQNIHPVTIGECPKYVRSTKLRMATGLRNIPSIQSR |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| M: THR28 SER31 TYR32 TYR52 ASP53 ARG55 ARG94 LEU96 LEU97 MET98 ASP99 PRO101 N: SER30 THR32 TYR49 SER50 LEU51 ASN52 GLN53 ARG54 LYS66 A: TYR98 LYS133 VAL135 SER145 TRP153 THR155 LYS156 GLY158 SER159 HIS183 PRO186 THR187 THR189 ASP190 GLN192 SER193 LEU194 GLN196 ALA219 ARG220 PRO221 LYS222 ASP225 GLN226 ALA227 GLY228 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
