Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 7492 |
| PDBID: | 6OKN |
| Chains: | AB_R |
| Organism: | Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 3.25 |
| Reference: | 10.1080/19420862.2019.1625662 |
| Antibody | |
| Antibody: | 1A7 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | Vonlerolizumab(Phase-II) |
| Antigen | |
| Antigen: | Tumor necrosis factor receptor superfamily member 4 (TNFRSF4) |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: A
Mutation: NULL
| >6OKN_A|Chain A, C|Fab 1A7 heavy chain|Homo sapiens (9606) EVQLVQSGAEVKKPGASVKVSCKASGYTFTDSYMSWVRQAPGQGLEWIGDMYPDNGDSSYNQKFRERVTITRDTSTSTAYLELSSLRSEDTAVYYCVLAPRWYFSVWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHL |
Light Chain: B
Mutation: NULL
| >6OKN_B|Chain B, D|Fab 1A7 light chain|Homo sapiens (9606) DIQMTQSPSSLSASVGDRVTITCRASQDISNYLNWYQQKPGKAPKLLIYYTSRLRSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQGHTLPPTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: R
Mutation: NULL
| >6OKN_R|Chain E, F[auth R]|Tumor necrosis factor receptor superfamily member 4|Homo sapiens (9606) MGSSHHHHHHSSGLVPRGSHMLHCVGDTYPSNDRCCHECRPGNGMVSRCSRSQNTVCRPCGPGFYNDVVSSKPCKPCTWCNLRSGSERKQLCTATQDTVCRCRAGTQPLDSYKPGVDCAPCPPGHFSPGDNQACKPWTNCTLAGKHTLQPASNSSDAICEDRD |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| A: GLU1 VAL2 GLY26 TYR27 THR28 ASP31 SER32 TYR33 TYR52 ASP57 LEU98 PRO100 ARG101 TRP102 TYR103 SER105 VAL106 B: TYR32 LEU46 TYR49 TYR50 ARG53 LEU54 ARG55 SER56 GLY91 HIS92 R: ASN88 ARG90 SER91 GLN114 PRO115 LEU116 ASP117 SER118 TYR119 VAL123 ASP124 CYS125 ALA126 PRO127 CYS128 PRO129 PRO130 HIS132 ASN138 ALA140 CYS141 LYS142 PRO143 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
