Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 7491 |
| PDBID: | 6OKM |
| Chains: | HL_R |
| Organism: | Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 2.10 |
| Reference: | 10.1080/19420862.2019.1625662 |
| Antibody | |
| Antibody: | 3C8 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Tumor necrosis factor receptor superfamily member 4 (TNFRSF4) |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >6OKM_H|Chain A[auth H]|Fab 3C8 Heavy Chain|Homo sapiens (9606) EVQLVQSGAEVKKPGASVKVSCKASGYAFTNYLIEWVRQAPGQGLEWIGVINPGSGDTYYSEKFKGRVTLTADTSTSTAYLELSSLRSEDTAVYYCARDRLDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHL |
Light Chain: L
Mutation: NULL
| >6OKM_L|Chain B[auth L]|Fab 3C8 light chain|Homo sapiens (9606) DIQMTQSPSSLSASVGDRVTITCHASQDISSYIVWYQQKPGKSFKGLIYHGTNLESGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCVHYAQFPYTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: R
Mutation: NULL
| >6OKM_R|Chain C[auth R]|Tumor necrosis factor receptor superfamily member 4|Homo sapiens (9606) MGSSHHHHHHSSGLVPRGSHMLHCVGDTYPSNDRCCHECRPGNGMVSRCSRSQNTVCRPCGPGFYNDVVSSKPCKPCTWCNLRSGSERKQLCTATQDTVCRCRAGTQPLDSYKPGVDCAPCPPGHFSPGDNQACKPWTNCTLAGKHTLQPASNSSDAICEDRD |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| H: THR30 ASN31 TYR32 LEU33 VAL50 ASN52 ASP57 THR58 TYR59 ARG98 ASP99 ARG100 ASP102 L: TYR32 VAL34 TYR49 ASN53 LEU54 GLU55 SER56 GLY57 VAL58 SER60 TYR91 ALA92 GLN93 PHE94 TYR96 R: PRO66 CYS67 GLY68 PRO69 GLY70 PHE71 CYS81 LYS82 PRO83 CYS84 TRP86 CYS87 ASN88 LEU89 ARG90 ARG95 LYS96 GLN97 LEU98 CYS99 THR100 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
