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Entry information

Complex
AACDB_ID: 749
PDBID: 4GFT
Chains: B_A
Organism: Plasmodium falciparum 3D7, Lama glama
Method: XRD
Resolution (Å): 1.60
Reference: 10.1016/j.molbiopara.2013.06.003
Antibody
Antibody: anti-MTIP Nanobody
Antibody mutation: No
INN (Clinical Trial):
Antigen
Antigen: Myosin A tail domain interacting protein
Antigen mutation: Yes
Durg Target:

Sequence information

Antibody

Chain: B
Mutation: NULL

>4GFT_B|Chain B|Nanobody|LAMA GLAMA (9844)
QVQLQESGGGTVQPGGSLKLSCSAAPERAFSNYAMGWFRQAPGQEREFVAGITGSGRSQYYADSVKGRFTISRDNAMNAVYLQMNSVKAEDTAVYYCAARVVPVFSDSTKGYVYWGQGTQVTVSSHHHHHHEPEA

Antigen

Chain: A
Mutation: C20S

>4GFT_A|Chain A|Myosin A tail domain interacting protein|Plasmodium falciparum 3D7 (36329)
GDKDNVEELIKMFAHFDNNSTGYLTKSQMKNILTTWGDALTDQEAIDALNAFSSEDNIDYKLFCEDILQ

Interaction

1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.

Interacting residues (ΔSASA based)

B: VAL3 GLU28 ARG29 TYR34 ARG101 VAL102 VAL103 VAL105 PHE106 SER107 LYS111 GLY112 TYR113 VAL114 TYR115

A: VAL141 ALA174 LEU175 THR176 GLN178 GLU179 ASP182 ALA183 ALA186 ASP201 ILE202 LEU203 GLN204

2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.

Interacting residues (Atom distance based)

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