Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 7474 |
| PDBID: | 6ID4 |
| Chains: | CD_F |
| Organism: | Homo sapiens, Human immunodeficiency virus 1 |
| Method: | XRD |
| Resolution (Å): | 2.40 |
| Reference: | 10.1038/s41467-019-08790-1 |
| Antibody | |
| Antibody: | 2E3 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | beta-2-microglobulin (β2m) |
| Antigen mutation: | No |
| Durg Target: | P61769 |
Sequence information
Antibody
Heavy Chain: C
Mutation: NULL
| >6ID4_C|Chain C, G[auth H]|Heavy chain|Homo sapiens (9606) EVQLVQSGAEVKKPGASVKVSCKASGYTFTGYYMHWVRQAPGQGLEWMGWINPNSGGTSYAQKFQGRVTMTRDTSTSTVYMELSSLRSEDTAVYYCARVTTVIAGPVFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPK |
Light Chain: D
Mutation: NULL
| >6ID4_D|Chain D, H[auth L]|Light chain|Homo sapiens (9606) QAVLTQPSSLSASPGASASLTCTLRSGINVGPYNIYWYQQKPGSPPQYLMRYKSDPDKHQGSAVPSRFSGSKDASANAGILLISGLQSEDEADYYCMIWHNNAWVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHKSYSCQVTHEGSTVEKTVAPTECS |
Antigen
Chain: F
Mutation: NULL
| >6ID4_F|Chain B, F|Beta-2-microglobulin|Homo sapiens (9606) MIQRTPKIQVYSRHPAENGKSNFLNCYVSGFHPSDIEVDLLKNGERIEKVEHSDLSFSKDWSFYLLYYTEFTPTEKDEYACRVNHVTLSQPKIVKWDRDM |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| C: GLY26 TYR27 THR28 TYR32 ARG98 THR100 THR101 VAL102 ILE103 ALA104 F: ASP34 ILE35 GLU36 ASP38 ARG45 GLU47 VAL49 ASN83 HIS84 VAL85 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
