Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 7472 |
| PDBID: | 6ID4 |
| Chains: | CD_E |
| Organism: | Homo sapiens, Human immunodeficiency virus 1 |
| Method: | XRD |
| Resolution (Å): | 2.40 |
| Reference: | 10.1038/s41467-019-08790-1 |
| Antibody | |
| Antibody: | 2E3 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Human leukocyte antigen allele HLA-A*11:01 |
| Antigen mutation: | No |
| Durg Target: | P04439 |
Sequence information
Antibody
Heavy Chain: C
Mutation: NULL
| >6ID4_C|Chain C, G[auth H]|Heavy chain|Homo sapiens (9606) EVQLVQSGAEVKKPGASVKVSCKASGYTFTGYYMHWVRQAPGQGLEWMGWINPNSGGTSYAQKFQGRVTMTRDTSTSTVYMELSSLRSEDTAVYYCARVTTVIAGPVFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPK |
Light Chain: D
Mutation: NULL
| >6ID4_D|Chain D, H[auth L]|Light chain|Homo sapiens (9606) QAVLTQPSSLSASPGASASLTCTLRSGINVGPYNIYWYQQKPGSPPQYLMRYKSDPDKHQGSAVPSRFSGSKDASANAGILLISGLQSEDEADYYCMIWHNNAWVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHKSYSCQVTHEGSTVEKTVAPTECS |
Antigen
Chain: E
Mutation: NULL
| >6ID4_E|Chain A, E|MHC class I antigen|Homo sapiens (9606) MGSHSMRYFYTSVSRPGRGEPRFIAVGYVDDTQFVRFDSDAASQRMEPRAPWIEQEGPEYWDQETRNVKAQSQTDRVDLGTLRGYYNQSEDGSHTIQIMYGCDVGPDGRFLRGYRQDAYDGKDYIALNEDLRSWTAADMAAQITKRKWEAAHAAEQQRAYLEGRCVEWLRRYLENGKETLQRTDPPKTHMTHHPISDHEATLRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDGTFQKWAAVVVPSGEEQRYTCHVQHEGLPKPLTLRWE |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| C: TYR33 HIS35 TRP50 ASN52 ASN54 SER55 ARG72 VAL99 THR100 THR101 ILE103 ALA104 GLY105 PRO106 VAL107 D: PRO29 TYR30 ASN31 TYR33 LYS50 TRP90 ASN92 ASN93 TRP95 E: VAL12 ARG14 PRO15 GLY16 ARG17 GLY18 GLU19 SER38 ASP39 ALA40 ALA41 GLN43 SER88 GLU89 ASP90 GLY91 SER92 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
