Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 747 |
| PDBID: | 4G80 |
| Chains: | EF_T |
| Organism: | Ciona intestinalis, Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 3.58 |
| Reference: | 10.1038/nsmb.2768 |
| Antibody | |
| Antibody: | 39D10_18 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Voltage-sensor containing phosphatase |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: E
Mutation: NULL
| >4G80_E|Chain B[auth A], D[auth C], G[auth E], I[auth G]|fragment antibody heavy chain|Homo sapiens (9606) EVQLVESGGGLVQPGGSLRLSCAASGFNVYYSSIHWVRQAPGKGLEWVAYISPSSGSTYYADSVKGRFTISADTSKNTAYLQMNSLRAEDTAVYYCARKQYSYWRDSYWAMDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEP |
Light Chain: F
Mutation: NULL
| >4G80_F|Chain C[auth B], E[auth D], H[auth F], J[auth H]|fragment antibody light chain|Homo sapiens (9606) DIQMTQSPSSLSASVGDRVTITCRASQSVSSAVAWYQQKPGKAPKLLIYSASSLYSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQHQYNSLIFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQAGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNR |
Antigen
Chain: T
Mutation: NULL
| >4G80_T|Chain A[auth I], F[auth J], K[auth S], L[auth T]|Voltage-sensor containing phosphatase|Ciona intestinalis (7719) MRGSHHHHHHGENLYFQFRVRAVIDHLGMRVFGVFLIFLDIILMIIDLSLPGKSESSQSFYDGMALALSCYFMLDLGLRIFAYGPKNFFTNPWEVADGLIIVVTFVVTIFYTVLDEYVQETGADGLGRLVVLARLLRVVRLARIFYSHQQMKASS |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| E: TYR50 SER54 SER55 SER57 TYR59 TYR101 SER102 TYR103 TRP104 ARG105 ASP106 F: SER30 SER31 GLN92 TYR93 ASN94 T: GLU144 GLN147 SER148 ASP151 GLY152 TYR200 THR201 VAL202 LEU203 ASP204 GLU205 VAL207 GLN208 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
