Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 7469 |
| PDBID: | 6HJQ |
| Chains: | IJ_C |
| Organism: | Influenza A virus (A/mallard/Alberta/35/1976(H1N1)), Homo sapiens |
| Method: | EM |
| Resolution (Å): | 4.10 |
| Reference: | 10.1073/pnas.1810927115 |
| Antibody | |
| Antibody: | FISW84 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Full-length Influenza A virus duck/Alberta/35/76 H1N1 hemagglutinin |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: I
Mutation: NULL
| >6HJQ_I|Chain C[auth G], E[auth I], F[auth K]|Heavy chain of FISW84 Fab|Homo sapiens (9606) EVQLLESGGGLVQPGGSLRLSCAASGFTFSSYGMAWVRQAPGKGLEWVSFISATGLSTYFADSVKGRFTISRDTTKNTLYLQMNSLRADDTAVYFCARMRRTMIAFGGNDFWGQGTLVTVSSASTKGPSVFPLAPSGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEP |
Light Chain: J
Mutation: NULL
| >6HJQ_J|Chain D[auth H], G[auth J], H[auth L]|Light chain of FISW84 Fab|Homo sapiens (9606) EVVMTQSPATLSVSPGEGATLSCRASQSVNTNVAWYQQKPGQAPRLLIYGASTRATGIPARFSGSGSGTEFTLTISTLQSEDFAVYYCQQYSNWPPITFGQGTRLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGE |
Antigen
Chain: C
Mutation: NULL
| >6HJQ_C|Chain A, I[auth C], J[auth E]|Hemagglutinin|Influenza A virus (strain A/Duck/Alberta/35/1976 H1N1) (352520) DTICVGYHANNSTDTVDTVLEKNVTVTHSVNLLEDSHNGKLCSLNGIAPLQLGKCNVAGWLLGNPECDLLLTANSWSYIIETSNSENGTCYPGEFIDYEELREQLSSVSSFEKFEIFPKASSWPNHETTKGVTAACSYSGASSFYRNLLWITKKGTSYPKLSKSYTNNKGKEVLVLWGVHHPPSVSEQQSLYQNADAYVSVGSSKYNRRFAPEIAARPKVRGQAGRMNYYWTLLDQGDTITFEATGNLIAPWYAFALNKGSDSGIITSDAPVHNCDTRCQTPHGALNSSLPFQNVHPITIGECPKYVKSTKLRMATGLRNVPSI |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| I: SER57 TYR59 ARG101 MET103 ILE104 C: ASP5 THR6 CYS8 SER326 ILE327 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
