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Entry information

Complex
AACDB_ID: 7468
PDBID: 6HJQ
Chains: GH_A
Organism: Influenza A virus (A/mallard/Alberta/35/1976(H1N1)), Homo sapiens
Method: EM
Resolution (Å): 4.10
Reference: 10.1073/pnas.1810927115
Antibody
Antibody: FISW84 Fab
Antibody mutation: No
INN (Clinical Trial):
Antigen
Antigen: Full-length Influenza A virus duck/Alberta/35/76 H1N1 hemagglutinin
Antigen mutation: No
Durg Target:

Sequence information

Antibody

Heavy Chain: G
Mutation: NULL

>6HJQ_G|Chain C[auth G], E[auth I], F[auth K]|Heavy chain of FISW84 Fab|Homo sapiens (9606)
EVQLLESGGGLVQPGGSLRLSCAASGFTFSSYGMAWVRQAPGKGLEWVSFISATGLSTYFADSVKGRFTISRDTTKNTLYLQMNSLRADDTAVYFCARMRRTMIAFGGNDFWGQGTLVTVSSASTKGPSVFPLAPSGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEP

Light Chain: H
Mutation: NULL

>6HJQ_H|Chain D[auth H], G[auth J], H[auth L]|Light chain of FISW84 Fab|Homo sapiens (9606)
EVVMTQSPATLSVSPGEGATLSCRASQSVNTNVAWYQQKPGQAPRLLIYGASTRATGIPARFSGSGSGTEFTLTISTLQSEDFAVYYCQQYSNWPPITFGQGTRLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGE

Antigen

Chain: A
Mutation: NULL

>6HJQ_A|Chain A, I[auth C], J[auth E]|Hemagglutinin|Influenza A virus (strain A/Duck/Alberta/35/1976 H1N1) (352520)
DTICVGYHANNSTDTVDTVLEKNVTVTHSVNLLEDSHNGKLCSLNGIAPLQLGKCNVAGWLLGNPECDLLLTANSWSYIIETSNSENGTCYPGEFIDYEELREQLSSVSSFEKFEIFPKASSWPNHETTKGVTAACSYSGASSFYRNLLWITKKGTSYPKLSKSYTNNKGKEVLVLWGVHHPPSVSEQQSLYQNADAYVSVGSSKYNRRFAPEIAARPKVRGQAGRMNYYWTLLDQGDTITFEATGNLIAPWYAFALNKGSDSGIITSDAPVHNCDTRCQTPHGALNSSLPFQNVHPITIGECPKYVKSTKLRMATGLRNVPSI

Interaction

1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.

Interacting residues (ΔSASA based)

G: SER57 TYR59 ARG101 MET103 ILE104

A: ASP5 THR6 CYS8 SER326 ILE327

2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.

Interacting residues (Atom distance based)

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