Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 7461 |
| PDBID: | 6HJP |
| Chains: | KL_F |
| Organism: | Influenza A virus (A/mallard/Alberta/35/1976(H1N1)), Homo sapiens |
| Method: | EM |
| Resolution (Å): | 3.30 |
| Reference: | 10.1073/pnas.1810927115 |
| Antibody | |
| Antibody: | FISW84 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Ectodomain of Influenza A virus duck/Alberta/35/76 H1N2 hemagglutinin |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: K
Mutation: NULL
| >6HJP_K|Chain G, I, J[auth K]|Heavy chain of FISW84 Fab Fragment|Homo sapiens (9606) EVQLLESGGGLVQPGGSLRLSCAASGFTFSSYGMAWVRQAPGKGLEWVSFISATGLSTYFADSVKGRFTISRDTTKNTLYLQMNSLRADDTAVYFCARMRRTMIAFGGNDFWGQGTLVTVSSASTKGPSVFPLAPSGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEP |
Light Chain: L
Mutation: NULL
| >6HJP_L|Chain H, K[auth J], L|Light chain of FISW84 Fab Fragment|Homo sapiens (9606) EVVMTQSPATLSVSPGEGATLSCRASQSVNTNVAWYQQKPGQAPRLLIYGASTRATGIPARFSGSGSGTEFTLTISTLQSEDFAVYYCQQYSNWPPITFGQGTRLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGE |
Antigen
Chain: F
Mutation: NULL
| >6HJP_F|Chain B, D, F|Hemagglutinin|Influenza A virus (strain A/Duck/Alberta/35/1976 H1N1) (352520) GLFGAIAGFIEGGWTGMIDGWYGYHHQNEQGSGYAADQKSTQNAIDGITSKVNSVIEKMNTQFTAVGKEFNNLERRIENLNKKVDDGFLDVWTYNAELLVLLENERTLDFHDSNVRNLYEKVKSQLRNNAKEIGNGCFEFYHKCDDECMESVKNGTYDYPKYSEESKLNREEID |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| K: PHE50 SER52 THR54 GLY55 LEU56 SER57 THR58 TYR59 PHE60 LYS65 THR102 MET103 ILE104 ALA105 L: ASN30 ASN32 SER92 ASN93 TRP94 PRO95 F: GLY16 HIS25 HIS26 GLN27 ASN28 GLU29 GLN30 GLY31 SER32 TYR34 LYS131 ILE133 ASN135 CYS137 GLU139 PHE140 TYR141 ASN169 ILE173 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
