Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 7446 |
| PDBID: | 6FGB |
| Chains: | HL_A |
| Organism: | Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 2.90 |
| Reference: | 10.1080/19420862.2018.1505464 |
| Antibody | |
| Antibody: | Rozanolixizumab Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | Rozanolixizumab(Approved) |
| Antigen | |
| Antigen: | Human FcRn extra-cellular domain |
| Antigen mutation: | No |
| Durg Target: | P55899 |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >6FGB_H|Chain D[auth H]|1519.g57- Heavy chain|Homo sapiens (9606) EVPLVESGGGLVQPGGSLRLSCAVSGFTFSNYGMVWVRQAPGKGLEWVAYIDSDGDNTYYRDSVKGRFTISRDNAKSSLYLQMNSLRAEDTAVYYCTTGIVRPFLYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCAA |
Light Chain: L
Mutation: NULL
| >6FGB_L|Chain C[auth L]|1519.g57- Light chain|Homo sapiens (9606) DIQMTQSPSSLSASVGDRVTITCKSSQSLVGASGKTYLYWLFQKPGKAPKRLIYLVSTLDSGIPSRFSGSGSGTEFTLTISSLQPEDFATYYCLQGTHFPHTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: A
Mutation: NULL
| >6FGB_A|Chain A|IgG receptor FcRn large subunit p51|Homo sapiens (9606) AESHLSLLYHLTAVSSPAPGTPAFWVSGWLGPQQYLSYNSLRGEAEPCGAWVWENQVSWYWEKETTDLRIKEKLFLEAFKALGGKGPYTLQGLLGCELGPDNTSVPTAKFALNGEEFMNFDLKQGTWGGDWPEALAISQRWQQQDKAANKELTFLLFSCPHRLREHLERGRGNLEWKEPPSMRLKARPSSPGFSVLTCSAFSFYPPELQLRFLRNGLAAGTGQGDFGPNSDGSFHASSSLTVKSGDEHHYCCIVQHAGLAQPLRVELESPAKSSVLVVGIVIGVLLLTAAAVGGALLWRRMRSGLPAPWISLRGDDTGVLLPTPGEAQDADLKDVNVIPATA |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| L: ALA32 SER33 LYS35 TYR37 TYR39 ARG51 TYR54 LEU55 H: SER25 GLY26 PHE27 THR28 SER30 ASN31 TYR32 SER53 ASP54 ASN74 ALA75 LYS76 SER77 ILE100 VAL101 ARG102 PRO103 TYR106 A: LEU93 GLU97 GLY99 PRO100 THR103 VAL105 PRO106 THR107 ALA108 LYS109 ASN113 GLU115 GLU116 PHE117 MET118 ASN119 PHE120 ASP121 LEU122 LYS123 GLN124 GLY128 GLY129 ASP130 TRP131 PRO132 GLU133 LEU135 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
