Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 7423 |
| PDBID: | 6EJG |
| Chains: | D_B |
| Organism: | Homo sapiens, Mus musculus |
| Method: | XRD |
| Resolution (Å): | 2.82 |
| Reference: | 10.1016/j.jmb.2018.05.018 |
| Antibody | |
| Antibody: | 4 scFv |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Host antigen CD81 |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Chain: D
Mutation: NULL
| >6EJG_D|Chain C, D|SINGLE CHAIN FV FRAGMENT|Mus musculus (10090) DIVLTQSPASLSVSLGQRATISCRASKSVSTSIYSYMHWYQQKPGQPPKLLIKYASYLESGVPARFSGSGSGTDFTLNIHPVEEEDAATYYCEHSREFPFTFGTGTKLEIKGGGGSGGGGSGGGGSGGGGSQVQLQQSGPELVKPGASVKISCKASGYTFSSSWMNWVKQRPGKGLEWIGRIYSGDGDAIYNGKFKGKATLTADKSSSTAYMQLSSLTSEDSAVYFCAREGKTGDLLLRSWGQGSALTVSS |
Antigen
Chain: B
Mutation: NULL
| >6EJG_B|Chain A, B|CD81 antigen|Homo sapiens (9606) GSGFVNKDQIAKDVKQFYDQALQQAVVDDDANNAKAVVKTFHETLDCCGSSTLTALTTSVLKNNLCPSGSNIISNLFKEDCHQKIDDLFSGKLHHHHHH |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| D: THR69 SER70 ILE71 TYR72 TYR74 TYR92 ARG134 GLU135 PHE136 TRP202 ARG219 TYR221 ASP224 ASP226 ALA227 ILE228 LYS270 THR271 GLY272 ASP273 LEU274 B: GLN125 GLN129 GLN132 GLN133 ALA134 VAL135 VAL136 ASP137 ASP138 LYS144 THR161 LEU162 THR163 ALA164 LEU165 THR167 SER168 LYS171 ASN172 ASN180 ILE181 ILE182 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
