Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 7420 |
| PDBID: | 6DFJ |
| Chains: | HL_E |
| Organism: | Homo sapiens, dengue virus type 1 |
| Method: | XRD |
| Resolution (Å): | 2.07 |
| Reference: | 10.1016/j.celrep.2018.10.031 |
| Antibody | |
| Antibody: | Z021 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Dengue 1 Envelope DIII domain |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >6DFJ_H|Chain A[auth H]|anti-Zika antibody Z021, Heavy Chain|Homo sapiens (9606) QVQLQESGPGLVKPSETLSLTCTVSGGSIDTYYWSWIRQTPGKGLEWIGCFYYSVDNHFNPSLESRVTISVDTSKNQFSLKMTSMTASDTAVYYCARNQPGGRAFDYWGPGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHHHHHH |
Light Chain: L
Mutation: NULL
| >6DFJ_L|Chain B[auth L]|anti-Zika antibody Z021, Light Chain|Homo sapiens (9606) EIVLTQSPATLSLSPGQRATLSCRASQSVSNYFAWYQQKPGQAPRLLIYDTSKRATGTPARFSGSGSGTDFTLTISSLEPEDFAVYYCQERNNWPLTWTFGLGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: E
Mutation: NULL
| >6DFJ_E|Chain C[auth E]|Dengue 1 Envelope DIII domain|Dengue virus 1 (11053) SYVMCTGSFKLEKEVAETQHGTVLVQVKYEGTDAPCKIPFSSQDEKGVTQNGRLITANPIVTDKEKPVNIEAEPPFGESYIVVGAGEKALKLSWFKKGS |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| H: THR31 TYR32 TYR33 TYR52 VAL55 ASP56 HIS58 ARG94 GLN96 PRO97 GLY98 GLY99 L: TYR32 ASP50 LYS53 ARG91 ASN93 TRP94 TRP96 E: SER298 TYR299 VAL300 MET301 THR303 GLY304 GLY328 THR329 ASP330 ALA331 PRO332 LYS334 LYS361 GLU362 ALA382 GLY383 GLU384 LYS385 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
