Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 742 |
| PDBID: | 4G6M |
| Chains: | HL_A |
| Organism: | Homo sapiens, Mus musculus |
| Method: | XRD |
| Resolution (Å): | 1.81 |
| Reference: | 10.1016/j.jmb.2012.09.021 |
| Antibody | |
| Antibody: | gevokizumab Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | Gevokizumab(Phase-III) |
| Antigen | |
| Antigen: | Interleukin-1 beta |
| Antigen mutation: | No |
| Durg Target: | P01584 |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >4G6M_H|Chain B[auth H]|heavy chain of gevokizumab antibody binding fragment|homo Sapiens (9606) QVQLQESGPGLVKPSQTLSLTCSFSGFSLSTSGMGVGWIRQPSGKGLEWLAHIWWDGDESYNPSLKSRLTISKDTSKNQVSLKITSVTAADTAVYFCARNRYDPPWFVDWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEP |
Light Chain: L
Mutation: NULL
| >4G6M_L|Chain C[auth L]|light chain of gevokizumab antibody binding fragment|homo Sapiens (9606) DIQMTQSTSSLSASVGDRVTITCRASQDISNYLSWYQQKPGKAVKLLIYYTSKLHSGVPSRFSGSGSGTDYTLTISSLQQEDFATYFCLQGKMLPWTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGE |
Antigen
Chain: A
Mutation: NULL
| >4G6M_A|Chain A|Interleukin-1 beta|Homo sapiens (9606) PVRSLNCTLRDSQQKSLVMSGPYELKALHLQGQDMEQQVVFSMSFVQGEESNDKIPVALGLKEKNLYLSCVLKDDKPTLQLESVDPKNYPKKKMEKRFVFNKIEINNKLEFESAQFPNWYISTSQAENMPVFLGGTKGGQDITDFTMQFV |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| H: SER32 GLY33 TRP54 TRP55 ASP56 ASP58 GLU59 SER60 TYR102 ASP103 PRO104 TRP106 L: ASP1 GLN27 ASP28 SER30 TYR32 TYR50 LYS53 GLY91 LYS92 MET93 LEU94 TRP96 A: GLN48 VAL72 LEU73 LYS74 ASP75 GLN81 GLU83 SER84 VAL85 ASP86 ASN89 TYR90 LYS92 LYS94 MET95 GLU96 LYS97 ARG98 ALA115 GLN116 PHE117 PRO118 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
