Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 7419 |
| PDBID: | 6DFI |
| Chains: | HL_E |
| Organism: | Homo sapiens, Zika virus |
| Method: | XRD |
| Resolution (Å): | 2.48 |
| Reference: | 10.1016/j.celrep.2018.10.031 |
| Antibody | |
| Antibody: | Z021 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Zika virus envelope protein DIII |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >6DFI_H|Chain A[auth H]|anti-Zika antibody Z021, Heavy Chain|Homo sapiens (9606) QVQLQESGPGLVKPSETLSLTCTVSGGSIDTYYWSWIRQTPGKGLEWIGCFYYSVDNHFNPSLESRVTISVDTSKNQFSLKMTSMTASDTAVYYCARNQPGGRAFDYWGPGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHHHHHH |
Light Chain: L
Mutation: NULL
| >6DFI_L|Chain B[auth L]|anti-Zika antibody Z021, Light Chain|Homo sapiens (9606) EIVLTQSPATLSLSPGQRATLSCRASQSVSNYFAWYQQKPGQAPRLLIYDTSKRATGTPARFSGSGSGTDFTLTISSLEPEDFAVYYCQERNNWPLTWTFGLGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: E
Mutation: NULL
| >6DFI_E|Chain C[auth E]|Zika virus envelope protein DIII|Zika virus (64320) MRLKGVSYSLCTAAFTFTKIPAETLHGTVTVEVQYAGTDGPCKVPAQMAVDMQTLTPVGRLITANPVITESTENSKMMLELDPPFGDSYIVIGVGEKKITHHWHRSGSTI |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| Chain residues position delta_SASA
: residuesposition H: THR31 TYR32 TYR33 TYR52 VAL55 ASP56 HIS58 GLN96 PRO97 GLY98 GLY99 L: VAL29 SER30 TYR32 ASP50 LYS53 ARG91 ASN93 TRP94 TRP96 E: VAL303 SER304 TYR305 SER306 LEU307 THR309 ALA310 GLY334 THR335 ASP336 GLY337 PRO338 SER368 THR369 GLU370 VAL391 GLY392 GLU393 LYS394 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 6 Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 6 Å from any atom.
Interacting residues (Atom distance based)
