Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 7417 |
| PDBID: | 6CWG |
| Chains: | D_C |
| Organism: | Ricinus communis, Vicugna pacos |
| Method: | XRD |
| Resolution (Å): | 2.60 |
| Reference: | 10.1093/protein/gzy022 |
| Antibody | |
| Antibody: | A9 VHH |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Ricin toxin's enzymatic subunit (RTA) |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Chain: D
Mutation: NULL
| >6CWG_D|Chain B, D|VHH antibody|Vicugna pacos (30538) QVQLAESGGGLVQAGGSLKLSCAASGRDFSMYMLAWFRQAPGKEREFVAAIMCSGGGGGTYYADSMQGRFTISRDNAKKTVALQMNSLKPEDTAVYYCAASTTYCSATTYSSDRLYDFWGQGTQVTVSSEPKTPKPQ |
Antigen
Chain: C
Mutation: NULL
| >6CWG_C|Chain A, C|Ricin|Ricinus communis (3988) MIFPKQYPIINFTTAGATVQSYTNFIRAVRGRLTTGADVRHEIPVLPNRVGLPINQRFILVELSNHAELSVTLALDVTNAYVVGYRAGNSAYFFHPDNQEDAEAITHLFTDVQNRYTFAFGGNYDRLEQLAGNLRENIELGNGPLEEAISALYYYSTGGTQLPTLARSFIICIQMISEAARFQYIEGEMRTRIRYNRRSAPDPSVITLENSWGRLSTAIQESNQGAFASPIQLQRRNGSKFSVYDVSILIPIIALMVYRCAPPPSSQF |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| D: ARG27 ASP28 SER30 MET31 TYR32 CYS53 GLY55 GLY56 GLY57 THR102 THR103 TYR104 CYS105 SER106 ALA107 THR108 THR109 LEU115 C: TYR91 HIS94 PRO95 ASN97 ALA101 ILE104 GLN112 ASN113 ARG114 TYR115 THR116 PHE117 ALA118 PHE119 GLY120 ARG125 GLN128 TYR154 LEU161 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
