Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 7413 |
| PDBID: | 6C5V |
| Chains: | HL_B |
| Organism: | human gammaherpesvirus 4, Epstein-barr virus strain ag876, Homo sapiens |
| Method: | EM |
| Resolution (Å): | 4.80 |
| Reference: | 10.1016/j.immuni.2018.03.026 |
| Antibody | |
| Antibody: | AMMO1 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Epstein-Barr virus (EBV) envelope glycoprotein L |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >6C5V_H|Chain D[auth H]|Antibody Fab AMMO1 heavy chain|Homo sapiens (9606) QVQLVQSGADVKKPGASVKVSCKASGYTFIHFGISWVRQAPGQGLEWMGWIDTNNGNTNYAQSLQGRVTMTTDTSTGTAYMELRSLSTDDTAVYFCARALEMGHRSGFPFDYWGQGVLVTVSPASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSC |
Light Chain: L
Mutation: NULL
| >6C5V_L|Chain E[auth L]|Antibody Fab AMMO1 light chain|Homo sapiens (9606) SYELTQPPSVSVAPGQRATITCGGHNIGAKNVHWYQQKPGQAPVLVIQYDSDRPSGIPERFSGSNSGSTATLTISRVEAGDEADYYCQVWDSGRGHPLYVFGGGTKVTVLGQPKANPTVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS |
Antigen
Chain: B
Mutation: NULL
| >6C5V_B|Chain B|Envelope glycoprotein L|Human herpesvirus 4 (82830) MDAMKRGLCCVLLLCGAVFVSPSASWAYPCCHVTQLRAQHLLALENISDIYLVSNQTCDGFSLASLNSPKNGSNQLVISRCANGLNVVSFFISILKRSSSALTGHLRELLTTLETLYGSFSVEDLFGANLNRYAWHRGG |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| L: TYR2 HIS25 ASN26 ALA29 LYS30 ASP91 SER92 ARG94 B: LEU123 PHE124 GLY125 ALA126 ASN127 LEU128 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
