Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 7410 |
| PDBID: | 6BT3 |
| Chains: | FE_L |
| Organism: | Mus musculus, Human papillomavirus 16 |
| Method: | EM |
| Resolution (Å): | 4.70 |
| Reference: | 10.3390/v9120374 |
| Antibody | |
| Antibody: | H16.V5 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Human papillomavirus (HPV) major capsid protein L1 |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: F
Mutation: NULL
| >6BT3_F|Chain B, D, F, H|V5 Fab Heavy-chain|Mus musculus (10090) EVKLEQSGAELARPGASVKLSCKASGYTFASYWMQWVKQRPGQGLEWIGAIYPGDGDTWYTQKFKGKATLTADKSSSTAYMQLSSLASEDSAVYYCARPPYYYGTTYYFDYWGQGTTLTVSGAKTTAPSVYPLAPAAGAAGAGSSVTLGCLVKGYFPEPVTLTWNSGSLSSGVHTFPAVLADLYTLSSSVTVTSSTWPAESITCNVAHPASSTKVDKKIEPRG |
Light Chain: E
Mutation: NULL
| >6BT3_E|Chain A, C, E, G|V5 Fab Light-chain|Mus musculus (10090) DIVMTQSPSSLAMSVGQKVTMSCKSSQSLLDSRNQKNYLAWYQQKPGQSPKLLVYFASTRESGVPDRFIGSGSGTDFTLTISSVQAEDLADYFCQQHYSTPLTFGAGTKLELKRADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWAIDGAERAGGVLNSFTGQDSKDSTYSMSSTLTLTKDEYERHASYTCEATHKTSTAPIVKSFNRGAA |
Antigen
Chain: L
Mutation: NULL
| >6BT3_L|Chain I, J, K, L, M, N|Major capsid protein L1|Human papillomavirus type 16 (333760) MSLWLPSEATVYLPPVPVSKVVSTDEYVARTNIYYHAGTSRLLAVGHPYFPIKKPNNNKILVPKVSGLQYRVFRIHLPDPNKFGFPDTSFYNPDTQRLVWACVGVEVGRGQPLGVGISGHPLLNKLDDTENASAYAANAGVDNRECISMDYKQTQLCLIGCKPPIGEHWGKGSPCTNVAVNPGDCPPLELINTVIQDGDMVDTGFGAMDFTTLQANKSEVPLDICTSICKYPDYIKMVSEPYGDSLFFYLRREQMFVRHLFNRAGAVGENVPDDLYIKGSGSTANLASSNYFPTPSGSMVTSDAQIFNKPYWLQRAQGHNNGICWGNQLFVTVVDTTRSTNMSLCAAISTSETTYKNTNFKEYLRHGEEYDLQFIFQLCKITLTADVMTYIHSMNSTILEDWNFGLQPPPGGTLEDTYRFVTSQAIACQKHTPPAPKEDPLKKYTFWEVNLKEKFSADLDQFPLGRKFLLQAGLKAKPKFTLGKRKATPTTSSTSTTAKRKKR |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| E: ASP31 ARG33 ASN34 LYS36 TYR38 TYR98 SER99 THR100 F: SER31 TRP33 TYR52 GLY54 ASP55 ASP57 TRP59 ASP73 LYS74 SER75 TYR101 TYR102 GLY104 THR105 THR106 TYR107 L: ALA134 TYR135 ALA136 ASN138 ALA139 GLY140 VAL141 ASN181 PRO182 ASP184 GLY265 ALA266 VAL267 GLY268 GLU269 ASN270 ASP273 LYS278 GLY279 SER280 GLY281 SER282 THR283 ALA284 ASN285 LEU286 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
